443-31-2Relevant articles and documents
Preparation method of 6-hydroxyindole derivative
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Paragraph 0025; 0026, (2018/01/12)
The invention discloses a preparation method of a 6-hydroxyindole derivative tert-butyl 2-(6-hydroxy-1H-indole-3-yl)ethylcarbamic acid. A desired product is prepared from 6-hydroxyindole as a starting material through a Friedel-Crafts reaction, an amidation reaction, a reduction reaction and a tert-butoxycarbonyl protection reaction. The compound is an important pharmaceutical intermediate.
Facile synthesis of 6-hydroxyindole-3-acetic acid: On the structure of the aromatic subunit of nephilatoxin-1~6
Shinada, Tetsuro,Miyachi, Miki,Itagaki, Yasuhiro,Naoki, Hideo,Yoshihara, Kazuo,Nakajima, Terumi
, p. 7099 - 7102 (2007/10/03)
A facile synthesis of 6-hydroxyindole-3-acetic acid 1a, which is the proposed aromatic subunit of NPTX-1~6, is described. Radical cyclization of isonitrile 2 successfully afforded 9 in high yield. The aromatic subunit of NPTX-1~6 was confirmed as 4-hydroxyindole-3-acetic acid 12 by comparison of the 1H-NMR spectra with those of authentic 4- and 6-hydroxyindole-3-acetic acids.