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6-Hydroxytryptamine, also known as 6-HT, is a naturally occurring indolealkylamine and a positional isomer of serotonin. It is structurally similar to serotonin, with the hydroxyl group at the 6th carbon position instead of the 5th. 6-HT is found in various plants and has been identified in trace amounts in mammalian tissues. It is known to have various biological activities, including acting as a weak agonist at certain serotonin receptors, and has been studied for its potential role in plant defense mechanisms and as a research tool in neurobiology. Due to its structural similarity to serotonin, 6-HT can be used to investigate the functions and mechanisms of serotonin receptors in the central nervous system.

443-31-2

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443-31-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 443-31-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,4 and 3 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 443-31:
(5*4)+(4*4)+(3*3)+(2*3)+(1*1)=52
52 % 10 = 2
So 443-31-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H12N2O/c11-4-3-7-6-12-10-5-8(13)1-2-9(7)10/h1-2,5-6,12-13H,3-4,11H2

443-31-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(2-aminoethyl)-1H-indol-6-ol

1.2 Other means of identification

Product number -
Other names 6-hydroxytriptamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:443-31-2 SDS

443-31-2Relevant academic research and scientific papers

Preparation method of 6-hydroxyindole derivative

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Paragraph 0025; 0026, (2018/01/12)

The invention discloses a preparation method of a 6-hydroxyindole derivative tert-butyl 2-(6-hydroxy-1H-indole-3-yl)ethylcarbamic acid. A desired product is prepared from 6-hydroxyindole as a starting material through a Friedel-Crafts reaction, an amidation reaction, a reduction reaction and a tert-butoxycarbonyl protection reaction. The compound is an important pharmaceutical intermediate.

Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors

Cuny, Gregory D.,Ulyanova, Natalia P.,Patnaik, Debasis,Liu, Ji-Feng,Lin, Xiangjie,Auerbach, Ken,Ray, Soumya S.,Xian, Jun,Glicksman, Marcie A.,Stein, Ross L.,Higgins, Jonathan M.G.

scheme or table, p. 2015 - 2019 (2012/04/05)

Haspin is a serine/threonine kinase that phosphorylates Thr-3 of histone H3 in mitosis that has emerged as a possible cancer therapeutic target. High throughput screening of approximately 140,000 compounds identified the beta-carbolines harmine and harmol as moderately potent haspin kinase inhibitors. Based on information obtained from a structure-activity relationship study previously conducted for an acridine series of haspin inhibitors in conjunction with in silico docking using a recently disclosed crystal structure of the kinase, harmine analogs were designed that resulted in significantly increased haspin kinase inhibitory potency. The harmine derivatives also demonstrated less activity towards DYRK2 compared to the acridine series. In vitro mouse liver microsome stability and kinase profiling of a representative member of the harmine series (42, LDN-211898) are also presented.

Facile synthesis of 6-hydroxyindole-3-acetic acid: On the structure of the aromatic subunit of nephilatoxin-1~6

Shinada, Tetsuro,Miyachi, Miki,Itagaki, Yasuhiro,Naoki, Hideo,Yoshihara, Kazuo,Nakajima, Terumi

, p. 7099 - 7102 (2007/10/03)

A facile synthesis of 6-hydroxyindole-3-acetic acid 1a, which is the proposed aromatic subunit of NPTX-1~6, is described. Radical cyclization of isonitrile 2 successfully afforded 9 in high yield. The aromatic subunit of NPTX-1~6 was confirmed as 4-hydroxyindole-3-acetic acid 12 by comparison of the 1H-NMR spectra with those of authentic 4- and 6-hydroxyindole-3-acetic acids.

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