443-42-5

Usage

Uses

Used in Pharmaceutical Industry:
3,5-Difluoro-4-methoxyphenol is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 3,5-Difluoro-4-methoxyphenol serves as an intermediate in the production of agrochemicals, potentially enhancing crop protection and yield through its incorporation into pesticides or other agricultural products.
Used in Organic Synthesis:
3,5-Difluoro-4-methoxyphenol is utilized as a reagent in organic synthesis reactions, facilitating the creation of a wide array of organic compounds for diverse applications.
Used in Antiseptic and Disinfectant Products:
Leveraging its antibacterial and antifungal properties, 3,5-Difluoro-4-methoxyphenol is used as an active ingredient in antiseptic and disinfectant products, contributing to infection control and hygiene maintenance in various settings.

Upstream product

• 363-47-3 3,5-difluoro-4-methoxyaniline 
• 392-25-6 1,3-difluoro-2-methoxy-5-nitrobenzene 
• 84959-65-9 2,6-difluorobenzene-1,4-diol 
• 77-78-1 dimethyl sulfate 
• 28177-48-2 2,6-difluorophenol 
• 437-82-1 1,3-difluoro-2-methoxybenzene 
• 329-45-3 Methyl 3,5-difluoro-4-methoxybenzoate 
• 343-79-3 3,5-difluoro-4-methoxy-benzoic acid amide 
• 484-94-6 1-fluoro-2-methoxy-3-nitrobenzene 
• 437-83-2 3-fluoro-2-methoxyaniline 
• 319-60-8 3,5-difluoro-4-methoxybenzoic acid 

Downstream Products

• 348-92-5 5-(2,6-diiodo-4-nitro-phenoxy)-1,3-difluoro-2-methoxy-benzene 
• 400-84-0 4-(3,5-difluoro-4-methoxy-phenoxy)-3,5-diiodo-aniline; hydrochloride 

Relevant academic research and scientific papers

Rationally Designed Fluorescence .OH Probe with High Sensitivity and Selectivity for Monitoring the Generation of .OH in Iron Autoxidation without Addition of H2O2

The first sensitive fluorescence .OH probe (1) that is capable of monitoring the generation of trace .OH in iron autoxidation is presented. The probe 1 was designed by utilizing both the unique aromatic hydroxylation and the electrop

C-H borylation by platinum catalysis

Herein, we describe the platinum-catalyzed borylation of aromatic C-H bonds. N-Heterocyclic carbene-ligated platinum catalysts are found to be efficient catalysts for the borylation of aromatic C(sp2)-H bonds when bis(pinacolato)diboron is used as the boron source. The most remarkable feature of these Pt catalysts is their lack of sensitivity towards the degree of steric hindrance around the C-H bonds undergoing the borylation reaction. These Pt catalysts allow for the synthesis of sterically congested 2,6-disubstituted phenylboronic esters, which are otherwise difficult to synthesize using existing C-H borylation methods. Furthermore, platinum catalysis allows for the site-selective borylation of the C-H bonds ortho to fluorine substituents in fluoroarene systems. Preliminary mechanistic studies and work towards the synthetic application of this platinum catalyzed C-H borylation process are described.

C-H Functionalization at Sterically Congested Positions by the Platinum-Catalyzed Borylation of Arenes

Despite significant progress in the area of C-H bond functionalization of arenes, no general method has been reported for the functionalization of C-H bonds at the sterically encumbered positions of simple arenes, such as mesitylene. Herein, we report the development of the first platinum-based catalyst for C-H borylation of arenes and heteroarenes. Notably, this method exhibited high tolerance toward steric hindrance and provided rapid access to a series of 2,6-disubstituted phenylboronic esters, valuable building blocks for further elaborations.

Synthesis and evaluation of 1,4-naphthoquinone ether derivatives as SmTGR inhibitors and new anti-schistosomal drugs

Investigations regarding the chemistry and mechanism of action of 2-methyl-1,4-naphthoquinone (or menadione) derivatives revealed 3-phenoxymethyl menadiones as a novel anti-schistosomal chemical series. These newly synthesized compounds (1-7) and their di