437-83-2

Basic information

• Product Name: 3-Fluoro-2-methoxyaniline
• Synonyms: 3-FLUORO-2-METHOXYBENZENAMINE;3-FLUORO-2-METHOXYANILINE;3-FLUORO-2-METHOXY-PHENYLAMINE;3-fluoro-O-anisidine;3-Fuloro-2-methoxyaniline;3-Fluoro-2-methoxyaniline, JRD;3-Fluoro-2-methoxyan;3-Fluoro-2-methoxyaniline 99%
• CAS NO: 437-83-2
• Molecular Formula: C₇H₈FNO
• Molecular Weight: 141.14
• Product Categories: Miscellaneous;Amines;Phenyls & Phenyl-Het;Aryl Fluorinated Building Blocks;Building Blocks;C7-C8;Chemical Synthesis;Fluorinated Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks
• Mol File: 437-83-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 162 °C
• Boiling Point: 117-121 °C(lit.)
• Flash Point: 80 °C
• Appearance: /
• Density: 0.823 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.129mmHg at 25°C
• Refractive Index: n20/D 1.446(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.52±0.10(Predicted)
• CAS DataBase Reference: 3-Fluoro-2-methoxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoro-2-methoxyaniline(437-83-2)
• EPA Substance Registry System: 3-Fluoro-2-methoxyaniline(437-83-2)

Safety Data

• Hazard Codes: F,Xi,T
• Statements: 11-36/37/38-24/25
• Safety Statements: 16-26-36-45-36/37/39
• RIDADR: UN 1993 3/PG 1
• WGK Germany: 3
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 437-83-2(Hazardous Substances Data)

Usage

Uses

3-Fluoro-2-methoxyaniline is a reactant in the synthesis of hydroxyquinolines.

InChI:InChI=1/C7H8FNO/c1-10-7-5(8)3-2-4-6(7)9/h2-4H,9H2,1H3

Upstream product

• 320-76-3 2-fluoro-4-bromo-6-nitro-phenol 
• 399-96-2 4-amino-2-fluorophenol 
• 403-19-0 2-fluoro-4-nitrophenol 
• 367-12-4 2-fluorophenol 
• 2105-94-4 4-bromo-2-fluorophenol 
• 1526-17-6 2-fluoro-6-nitrophenol 
• 74266-66-3 bromo-4 fluoro-2 nitro-6 anisole 
• 484-94-6 1-fluoro-2-methoxy-3-nitrobenzene 

Downstream Products

• 345-47-1 4-nitro-benzoic acid-(3-fluoro-2-methoxy-anilide) 
• 74266-68-5 fluoro-3 methoxy-2 benzaldehhyde 
• 394-50-3 3-fluorosalicylaldehyde 
• 286369-94-6 N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N'-(3-fluoro-2-methoxyphenyl)urea 
• 928627-08-1 (E)-3-Ethoxy-N-(3-fluoro-2-methoxyphenyl)acrylamide 
• 32750-21-3 1-fluoro-3-iodo-2-methoxybenzene 
• 1067646-37-0 7-fluoro-8-hydroxyquinolin-2(1H)-one 

Relevant articles and documents

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.

NEW ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS

The invention provides certain compounds and salts of Formula I and Formula II:which possess antimicrobial activity. The invention also provides novel synthetic intermediatesuseful in making compounds of Formula I and Formula II. The variables A1, R2, R3, R5, R6, R7, A8, and Rg are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in animals.