443360-58-5

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 566188-75-8 3-methoxycarbonylallylidenetriphenylarsorane 
• 40230-95-3 1-(4-trifluoromethylphenyl)-2-trimethylsilylethyne 
• 705-31-7 4-trifluoromethylphenylacetylene 
• 292638-85-8 acrylic acid methyl ester 
• 125617-18-7 3-(4-trifluoromethylphenyl)-2-propen-1-ol 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 95123-61-8 (2E)-3-(4-trifluoromethylphenyl)prop-2-enal 
• 20754-22-7 methyl (2E)-3-(4-(trifluoromethyl)phenyl)prop-2-enoate 
• 1117-71-1 methyl-4-bromo-2-butenoate 
• 623-43-8 crotonic acid methyl ester 
• 67629-62-3 methyl 4-(diethylphosphono)crotonate 

Downstream Products

• 203722-39-8 (E,E)-5-(4-trifluoromethylphenyl)-2,4-pentadienoic acid 
• 443360-65-4 (2E,4E)-5-(4-Trifluoromethyl-phenyl)-penta-2,4-dienoyl chloride 
• 1369534-86-0 (2E,4E)-N-(isoquinolin-5-yl)-5-(4-trifluoromethylphenyl)-2,4-pentadienamide 

Relevant academic research and scientific papers

Microwave-accelerated Ru-catalyzed hydrovinylation of alkynes and enynes: A straightforward approach toward 1,3-dienes and 1,3,5-trienes

Quick, but not dirty! Microwave heating was found to have a significant effect on the Ru-catalyzed hydrovinylations of alkynes. A broad range of different terminal alkynes were coupled to methyl acrylate within just 30min in good to excellent yields (see scheme). This new protocol was transferred to the hydrovinylation of enynes as novel coupling partners in C-H-activation chemistry giving different 1,3,5-trienes as the sole products. Copyright

Discovery of novel 5,5-diarylpentadienamides as orally available transient receptor potential vanilloid 1 (TRPV1) antagonists

We have developed a novel and potent chemical series of 5,5-diphenylpentadienamides for targeting TRPV1 in vitro and in vivo. In this investigation, we examined a variety of replacements for the 5-position of dienamides with the goal of addressing issues related to pharmacokinetics. Our data suggest that substitution with alkoxy groups on the phenyl ring at the 5-position increases their ability to penetrate the blood-brain barrier. This investigation culminated in the discovery of compound (R)-36b, which showed a good pharmacokinetic profile. In vivo, compound (R)-36b was found to be effective at reversing mechanical allodynia in rats in a dose-dependent manner, and it reversed thermal hyperalgesia in a model of neuropathic pain induced by sciatic nerve injury.

Synthetic and spectroscopic studies of structural analogs of piper amides - The 5-aryl-2E,4E-pentadienamides

The methyl esters and piperidides of fourteen 5-aryl-2E,4E-pentadienoic acids have been synthesized starting from the corresponding aryl aldehydes.