4435-19-2

Basic information

• Product Name: 1-Oxaspiro[4.5]dec-3-en-2-one
• CAS NO: 4435-19-2
• Molecular Formula: C9H12O2
• Molecular Weight: 152.193
• Mol File: 4435-19-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-Oxaspiro[4.5]dec-3-en-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Oxaspiro[4.5]dec-3-en-2-one(4435-19-2)
• EPA Substance Registry System: 1-Oxaspiro[4.5]dec-3-en-2-one(4435-19-2)

Safety Data

• Hazardous Substances Data: 4435-19-2(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Fruity

Uses

Synthesis of pharmaceuticals and fragrance compounds, building block in organic compound production

Classification

Cyclic ether

Safety precautions

Causes skin, eye, and respiratory irritation; handle with care and store in a well-ventilated area, away from heat, sparks, and open flames.

Upstream product

• 108-94-1 cyclohexanone 
• 922-67-8 propynoic acid methyl ester 
• 108-93-0 cyclohexanol 
• 72036-33-0 methyl 3-(1-hydroxycyclohexyl)-2-propynoate 
• 82660-72-8 2',6'-exo-spirodioxatricyclo<5.2.1.0^2,6>dec-8'-en-3'-one> 
• 201230-82-2 carbon monoxide 
• 110295-98-2 1-((Z)-2-Phenyltellanyl-vinyl)-cyclohexanol 

Relevant articles and documents

Samarium (II) iodide-induced intermolecular coupling of a,b-unsaturated esters with ketones: Reactions of methyl propiolate and ethyl buta-2,3-dienoate with cyclohexanone and its application to synthesis of a terpene carboxylic acid

The reactions of methyl propiolate and ethyl buta-2,3-dienoate with cyclohexanone induced by SmI2 occurred either at a- or b-position to yield different products depending on with or without a proton source. The synthesis of terpenic acid was demonstrated using this reaction.

Trans-selective conversions of γ-hydroxy-α,β-alkynoic esters to γ-hydroxy-α,β-alkenoic esters

Matrix presented. γ-Hydroxy-α,β-acetylenic esters are used as precursors to prepare γ-hydroxy-α,β-alkenoic esters by means of trans-selective additions of two hydrogen atoms or one hydrogen atom and one iodine atom across the triple bonds. These methods a

Novel Synthesis of Five- and Six-Membered Spiro γ-Lactones in Rigid Bicyclic Systems

The reaction of bis(bromomagnesio)alkanes with bridged tricyclic endo- and exo-dicarboxylic anhydrides and their dihydro derivatives provides a general and versatile route to corresponding tricyclic spiro γ-butanolides.Futher extension of this methodology to the dianhydride of bicyclooctene showed appreciable regioselectivity.The subsequent transformation of spiro γ-lactones into 4-spiro-2-butenolides by retro-Diels-Alder reaction has provided a simple and convenient synthesis of these molecules.Proton and 13C NMR spectra are reported for most of the compounds.