443770-52-3

Upstream product

• 18677-43-5 2,4-dimethoxypyridine 

Downstream Products

• 443770-53-4 3-bromo-2,4-dimethoxy-5-(p-benzyloxyphenyl)pyridine 
• 790234-45-6 3-bromo-2,4-dimethoxy-5-(p-methoxyphenyl)pyridine 
• 443770-62-5 (2E,4E)-6-(hydroxymethyl)-1-[5-(p-benzyloxyphenyl)-2,4-dihydroxypyridine-3-yl]-4-methylocta-2,4-dien-1-one 
• 443770-59-0 (2E,4E)-6-(tert-butyldimethylsilanyloxymethyl)-1-[5-(p-benzyloxyphenyl)-2,4-dimethoxypyridine-3-yl]-4-methylocta-2,4-dien-1-ol 
• 443770-61-4 (2E,4E)-6-(tert-butyldimethylsilanyloxymethyl)-1-[5-(p-benzyloxyphenyl)-2,4-dimethoxypyridine-3-yl]-4-methylocta-2,4-dien-1-one 

Relevant academic research and scientific papers

Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors

Autophagy is a catabolic process, which mediates degradation of cellular components and has important roles in health and disease. Therefore, small molecule modulators of autophagy are in great demand. Herein, we describe a phenotypic high-content screen for autophagy inhibitors, which led to the discovery of a dimethoxypyridine-based class of autophagy inhibitors, which derive from previously reported, natural product-inspired MAP4K4 inhibitors. Comprehensive structure-activity relationship studies led to a potent compound, and biological validation experiments indicated that the mode of action was upstream or independent of mTOR.