4439-56-9

Basic information

• Product Name: NSC97553
• Synonyms: NSC97553;2-furylmethyl(phenyl)amine;N-(2-Furanylmethyl)aniline;N-Phenylfurfurylamine;N-(furan-2-ylmethyl) aniline analogue
• CAS NO: 4439-56-9
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 173.214
• Mol File: 4439-56-9.mol
• Article Data: 133

Chemical Properties

• Boiling Point: 281 °C at 760 mmHg
• Flash Point: 123.7 °C
• Appearance: /
• Density: 1.136 g/cm³
• Vapor Pressure: 0.00366mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: NSC97553(CAS DataBase Reference)
• NIST Chemistry Reference: NSC97553(4439-56-9)
• EPA Substance Registry System: NSC97553(4439-56-9)

Safety Data

• Hazardous Substances Data: 4439-56-9(Hazardous Substances Data)

Usage

General Description

NSC97553, also known as JNJ-26854165, is a small molecule inhibitor of the human sirtuin 1 (SIRT1) enzyme. SIRT1 is a protein deacetylase that is involved in a variety of cellular processes, including regulation of gene expression, DNA repair, and metabolism. NSC97553 has been studied for its potential as a cancer therapy due to its ability to induce apoptosis and inhibit cell proliferation in various cancer cell lines. It has also been investigated for its anti-inflammatory and neuroprotective effects. Research on NSC97553 is ongoing, and its potential as a therapeutic agent for various diseases continues to be explored.

InChI:InChI=1/C11H11NO/c1-2-5-10(6-3-1)12-9-11-7-4-8-13-11/h1-8,12H,9H2

Upstream product

• 98-00-0 (2-furyl)methyl alcohol 
• 2325-27-1 N-phenyltriphenyliminophosphorane 
• 591-50-4 iodobenzene 
• 617-89-0 furan-2-ylmethanamine 
• 62-53-3 aniline 
• 98-01-1 furfural 
• 4437-18-7 2-bromomethylfuran 
• 108-44-1 1-amino-3-methylbenzene 
• 100-68-5 methyl-phenyl-thioether 
• 98-95-3 nitrobenzene 
• 538-51-2 benzylidene phenylamine 
• 103-84-4 Acetanilid 
• 88-14-2 2-furanoic acid 
• 10257-32-6 D-ribose 

Downstream Products

• 953065-28-6 4-(((furan-2-ylmethyl)(phenyl)amino)methyl)quinolin-2(1H)-one 
• 5388-42-1 N-phenylphthalimidine 

Relevant articles and documents

Furfural and 5-(hydroxymethyl)furfural valorization using homogeneous Ni(0) and Ni(II) catalysts by transfer hydrogenation

The complex [dippeNi(COD)] (dippe =1,2-bis(diisopropyl phosphino)ethane) was used as a catalytic precursor in furfural (FF) and 5-(hydroxymethyl)furfural (HMF) valorization, along with formic acid as hydrogen transfer agent, to produce the corresponding a

Stable Ni catalyst encapsulated in N-doped carbon nanotubes for one-pot reductive amination of nitroarenes with aldehydes

A novel strategy involving a popping process and carbothermal reduction was developed to create a kind of stable nickel catalyst (Ni-NC). The popping process of the mixture being composed of carbon nitride (C3N4) and nickel nitrate decomposed the nickel nitrate into nickel (oxide) nanoparticles that afterwards functioned as catalyst to grow N-containing carbon nanotubes with carbon nitride as N-containing carbon source. Finally, the nickel catalyst possessed a special structure of nanoparticles encapsulated in N-doped carbon nanotubes. This special structure is helpful to prevent nickel nanoparticles from being oxidized in air for months so that the catalyst exhibits high stability in air atmosphere. As a practical application, this encapsulated nickel catalyst exhibited excellent catalytic activity and stability in one-pot cascade reaction involving nitro-reduction and reductive amination of nitroarenes.

BF3·Et2O as a metal-free catalyst for direct reductive amination of aldehydes with amines using formic acid as a reductant

A versatile metal- and base-free direct reductive amination of aldehydes with amines using formic acid as a reductant under the catalysis of inexpensive BF3·Et2O has been developed. A wide range of primary and secondary amines and diversely substituted aldehydes are compatible with this transformation, allowing facile access to various secondary and tertiary amines in high yields with wide functional group tolerance. Moreover, the method is convenient for the late-stage functionalization of bioactive compounds and preparation of commercialized drug molecules and biologically relevant N-heterocycles. The procedure has the advantages of simple operation and workup and easy scale-up, and does not require dry conditions, an inert atmosphere or a water scavenger. Mechanistic studies reveal the involvement of imine activation by BF3and hydride transfer from formic acid.