444020-51-3

Upstream product

• 942599-73-7 [1-(3,5-bis-trifluoromethyl-phenyl)-ethoxy]-acetic acid tert-butyl ester 
• 368-63-8 (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol 
• 444020-11-5 [1-(3,5-bis-trifluoromethyl-phenyl)-ethoxy]-acetic acid 

Downstream Products

• 886228-67-7 2-[1-(3,5-bis-trifluoromethyl-phenyl)-ethoxy]-4-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-1-morpholin-4-yl-pent-4-en-1-one 

Relevant academic research and scientific papers

Stereoselective synthesis of a potent human NK1 receptor antagonist via acyl-Claisen rearrangement

Stereoselective synthesis of the tetrahydropyran derivative 1 is reported. Diastereoselective acyl-Claisen rearrangement was employed for formation of C3 and C4 chiral centres on the tetrahydropyran ring. Georg Thieme Verlag Stuttgart.