444105-66-2

Upstream product

• 443761-68-0 (R)-3-[(2R,3S,4S)-3-[(tert-butyldimethylsilanyl)oxy]-5-hydroxy-2,4-dimethylpentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one 

Downstream Products

• 565229-57-4 carbamic acid, (1S,2S,3R,6Z,8S,9S,10S,11Z)-1-isopropyl-3,9-bis(4-methoxybenzyloxy)-14-[(2R,3R,4S,5R,6R)-6-methoxy-4-methoxymethoxy-3,5-dimethyltetrahydropyran-2-yl]-2,8,10-trimethyltetradeca-6,11-dienyl ester 
• 565229-93-8 (8Z,13Z)-(3S,4R,5R,10S,11R,12S)-5,11-Bis-(4-methoxy-benzyloxy)-16-((2S,3S,4S,5R,6R)-6-methoxy-4-methoxymethoxy-3,5-dimethyl-tetrahydro-pyran-2-yl)-2,4,10,12-tetramethyl-hexadeca-8,13-dien-3-ol 
• 565229-91-6 (6Z,11Z)-(2R,3R,8S,9R,10S)-3,9-Bis-(4-methoxy-benzyloxy)-14-((2S,3S,4S,5R,6R)-6-methoxy-4-methoxymethoxy-3,5-dimethyl-tetrahydro-pyran-2-yl)-2,8,10-trimethyl-tetradeca-6,11-dien-1-ol 
• 565229-49-4 (4S,5R)-4-{(3Z,5S,6S,7S,8Z)-6-(4-methoxybenzyloxy)-11-[(2S,3R,4S,5R,6R)-6-methoxy-4-methoxymethoxy-3,5-dimethyltetrahydropyran-2-yl]-5,7-dimethylundeca-3,8-dienyl}-2-(4-methoxyphenyl)-5-methyl[1,3]dioxane 
• 565229-53-0 (2S,3R,6Z,8S,9S,10S,11Z)-3,9-bis(4-methoxybenzyloxy)-14-[(2S,3R,4S,5R,6R)-6-methoxy-4-methoxymethoxy-3,5-dimethyltetrahydropyran-2-yl]-2,8,10-trimethyltetradeca-6,11-dienal 
• 565229-28-9 (4R,5S)-4-{(1S,2Z)-5-[(2S,3R,4S,5R,6R)-6-methoxy-4-methoxymethoxy-3,5-dimethyltetrahydropyran-2-yl]-1-methylpent-2-enyl}-2-(4-methoxyphenyl)-5-methyl[1,3]dioxane 
• 565229-36-9 (2R,3S,4S,5Z)-3-(4-methoxybenzyloxy)-8-[(2S,3R,4S,5R,6R)-6-methoxy-4-methoxymethoxy-3,5-dimethyltetrahydropyran-2-yl]-2,4-dimethyloct-5-enal 
• 845780-34-9 (2S,3R,4R,6S,9R,10S,11S,12S)-9,11,13-tris(tert-butyldimethylsilanyloxy)-3-(4-methoxybenzyloxy)-2,4,6,10,12-pentamethyltridecan-1-ol 
• 845780-48-5 1-methoxy-4-{(1R,2S)-2-methyl-1-[(1R,3S,6R,7S,8S,9S)-6,8,10-tris(tert-butyldimethylsilanyloxy)-1,3,7,9-tetramethyldecyl]but-3-enyloxymethyl}benzene 
• 845780-46-3 (2S,4R,5S)-2-(4-methoxyphenyl)-5-methyl-4-[(1R,3S,6R,7S,8S,9S)-6,8,10-tris(tert-butyldimethylsilanyloxy)-1,3,7,9-tetramethyldecyl]-[1,3]dioxane 
• 845780-45-2 (2S,3S,4S,5R,8S,10R)-1,3-bis(tert-butyldimethylsilanyloxy)-10-[(2S,4R,5S)-2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]-2,4,8-trimethylundecan-5-ol 
• 845780-44-1 (2S,3S,4R,8S,10R)-1,3-bis(tert-butyldimethylsilanyloxy)-10-[(2S,4R,5S)-2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]-2,4,8-trimethylundecan-5-one 
• 845780-33-8 (2S,3S,4R,8R,10R)-1,3-bis(tert-butyldimethylsilanyloxy)-10-[(2S,4R,5S)-2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]-2,4,8-trimethylundec-6-en-5-one 
• 303727-87-9 (2R,3S,4S)-3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,4-dimethyl-pentanoic acid N-methoxy-N-methyl-amide 

Relevant academic research and scientific papers

A practical building block for the synthesis of discodermolide

A new highly diastereoselective and practical route to the lactone 6a which is used as a key building block for the total synthesis of the microtubule-stabilizing anticancer agent discodermolide is reported. This exploits the chiral auxiliary (4R)-4-isopr