444150-07-6

Upstream product

• 1120-90-7 3-iodopyridine 
• 16013-13-1 3-(4-methoxyphenyl)-1,2,4-oxadiazole 
• 5373-87-5 N-hydroxy-4-methoxybenzene-1-carboximidamide 
• 874-90-8 4-methoxybenzonitrile 

Relevant academic research and scientific papers

Palladium-Catalyzed, Silver-Assisted Direct C-5–H Arylation of 3-Substituted 1,2,4-Oxadiazoles under Microwave Irradiation

A direct C-5–H arylation of 3-substituted 1,2,4-oxadiazoles with aryl iodides in the presence of a palladium catalyst and silver acetate is reported. This method provides a rapid, reliable way to obtain versatile 3,5-diaryl-1,2,4-oxadiazole derivatives, which are common moieties of many biologically active molecules. The synthetic applications of this novel method have been demonstrated in the concise syntheses of Ataluren and a potent RET inhibitor Yhhu251. (Figure presented.).