16013-13-1

Upstream product

• 5373-87-5 N-hydroxy-4-methoxybenzene-1-carboximidamide 
• 122-51-0 orthoformic acid triethyl ester 
• 102-52-3 malonaldehydebis(dimethylacetal) 
• 5373-87-5 4-methoxybenzamidoxime 
• 149-73-5 trimethyl orthoformate 
• 874-90-8 4-methoxybenzonitrile 

Downstream Products

• 75273-66-4 3-(4-methoxyphenyl)-5-phenyl-1,2,4-oxadiazole 
• 65205-55-2 3-(4-methoxyphenyl)-5-(4-methylphenyl)-1,2,4-oxadiazole 
• 55667-07-7 3,5-bis(4-methoxyphenyl)-1,2,4-oxadiazole 
• 89804-67-1 3-(4-methoxyphenyl)-5-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazole 
• 72094-41-8 4-(3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl)benzaldehyde 
• 444150-07-6 3-(4-methoxyphenyl)-5-(pyridin-3-yl)-1,2,4-oxadiazole 
• 444151-44-4 3-(4-methoxyphenyl)-5-(pyridin-4-yl)-1,2,4-oxadiazole 
• 381698-73-3 3-(4-methoxyphenyl)-5-(naphthalen-1-yl)-1,2,4-oxadiazole 

Relevant academic research and scientific papers

Palladium-Catalyzed, Silver-Assisted Direct C-5–H Arylation of 3-Substituted 1,2,4-Oxadiazoles under Microwave Irradiation

A direct C-5–H arylation of 3-substituted 1,2,4-oxadiazoles with aryl iodides in the presence of a palladium catalyst and silver acetate is reported. This method provides a rapid, reliable way to obtain versatile 3,5-diaryl-1,2,4-oxadiazole derivatives, which are common moieties of many biologically active molecules. The synthetic applications of this novel method have been demonstrated in the concise syntheses of Ataluren and a potent RET inhibitor Yhhu251. (Figure presented.).

An approach to pyrimidine N-oxides: Carboxamide oximes as precursors

A method for the synthesis of pyrimidines N-oxides is described. Various carboxamide oximes were treated with the appropriate 1,3-dicarbonyl compounds or their equivalents in the presence of trifluoroacetic acid as a catalyst to give the corresponding pyr