444151-79-5

Upstream product

• 769-42-6 1,3-dimethylbarbituric acid 
• 3446-89-7 4-(Methylthio)benzaldehyde 

Downstream Products

• 1172135-18-0 6-(4-methoxyphenyl)-1',3,3'-trimethyl-4-[4-(methylsulfanyl)phenyl]-1-phenyl-1,4,6,7-tetrahydro-2'H-spiro[pyrazolo[3,4-b]pyridine-5,5'-pyrimidine]-2',4',6'(1'H,3'H)-trione 

Relevant academic research and scientific papers

Substituent electrophilicities in the NMR spectra of barbituric derivatives

Comparison of the 1H and 13 C NMR spectra of a series of substituted 5-benzylidene-N,N′-dimethylbarbituric acids (1) revealed chemical-shift variations of different centers that correlated with the theoretical electrophilicities or with the substituent electrophilic constant σω, in an example of the usefulness of these DFT-based indices. Copyright

5-Arylidene N,N-dimethylbarbiturates as urease inhibitors

Earlier 5-arylidene N,N-dimethylbarbiturates 1-24 were reported by our group as novel antioxidant, nevertheless, urease inhibitory activity of these compounds has not been investigated at all. In the present study, compounds 1-24 were synthesized by the reaction of N,N-dimethylbarbituric acid with different aromatic aldehydes, and screened for their in vitro urease inhibitory effects. Compound 7, was found to be most active urease inhibitor in the series. Nonetheless, compounds 11, 12, and 19 were also active against urease enzyme.

Antibacterial and antifungal activities of 5-arylidene-N,N-dimethylbarbiturates derivatives

A series of N,N-dimethyl-arylidene barbiturates 1-22 has been re-synthesized and evaluated against a number of Gram-positive, Gram-negative bacteria and some fungal strains. Most of the compounds were found to be active against a number of Gram-positive, Gram-negative and also displayed anti-fungal activities.

Xanthine oxidase inhibition by 5-aryledene N,N'-dimethylbarbituric acid derivatives

N,N'-dimethylbarbituric acid derivatives 1-24 were evaluated for their xanthine oxidase (XO) inhibitory activity. Majority of these compounds showed a good to moderate in vitro xanthine oxidase inhibitory activity (IC50 = 20.97 ± 0.29 - 327.0 ± 3.50 μM), while eight compounds were found to be completely inactive. A structure-activity relationship has been discussed, identifying structural features, responsible for varying degree of activity.

Synthesis and DPPH radical scavenging activity of 5-arylidene-N, Ndimethylbarbiturates

Twenty-four derivatives of N,N-dimethylbarbituric acid 1-24 were screened for their DPPH radical scavenging activity. These compounds showed an excellent antioxidant activity. A structure-activity relationship has been discussed, while all the synthetic compounds were characterized by spectroscopic techniques and elemental analysis.