444188-89-0

Basic information

• Product Name: 7-(diethoxyphosphoryl)-3,7-diazabicyclo[4.1.0]heptane-3-carboxylic acid benzyl ester
• Synonyms: 7-(diethoxyphosphoryl)-3,7-diazabicyclo[4.1.0]heptane-3-carboxylic acid benzyl ester
• CAS NO: 444188-89-0
• Molecular Weight: 368.37
• Mol File: 444188-89-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 7-(diethoxyphosphoryl)-3,7-diazabicyclo[4.1.0]heptane-3-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(diethoxyphosphoryl)-3,7-diazabicyclo[4.1.0]heptane-3-carboxylic acid benzyl ester(444188-89-0)
• EPA Substance Registry System: 7-(diethoxyphosphoryl)-3,7-diazabicyclo[4.1.0]heptane-3-carboxylic acid benzyl ester(444188-89-0)

Safety Data

• Hazardous Substances Data: 444188-89-0(Hazardous Substances Data)

Upstream product

• 937-14-4 3-chloro-benzenecarboperoxoic acid 
• 174681-58-4 5,6-dihydropyridine-1(2H)-carboxylate 
• 66207-08-7 3,4-epoxy-piperidine-1-carboxylic acid benzyl ester 
• 66207-23-6 1-benzyloxycarbonyl-1,2,3,6-tetrahydropyridine 
• 501-53-1 benzyl chloroformate 
• 694-05-3 1,2,3,6-tetrahydropyridine 
• 814-49-3 diethyl chlorophosphate 
• 98-59-9 p-toluenesulfonyl chloride 
• 444188-88-9 benzyl 3,7-diazabicyclo[4.1.0]heptane-3-carboxylate 

Downstream Products

• 1187055-73-7 benzyl 3-(diethoxyphosphorylamino)-4-methylpiperidine-1-carboxylate 
• 1187055-77-1 benzyl 4-chloro-3-(diethoxyphosphorylamino)piperidine-1-carboxylate 
• 1449320-47-1 1-benzyl-1H-pyrazol-4-carboxylic acid [4-((3R,4R)-3-amino-4-cyclopropylpiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449320-69-7 (3R,4R)-4-cyclopropyl-3-(diethoxyphosphorylamino)piperidine-1-carboxylic acid benzyl ester 
• 1052713-46-8 tert-butyl-trans-4-fluoropiperidin-3-ylcarbamate 
• 250275-20-8 (+/-)-trans-3-(tert-butoxycarbonyl)amino-4-methylpiperidine 

Relevant articles and documents

1H-PYRROLO[2,3-B] PYRIDINE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS

The inventions relates to compounds of (I) and therapeutic uses thereof: (I) The terms Z, Y, and R1 are as defined in the claims.

Pim kinase inhibitors and methods of their use

The present invention relates to new compounds of Formulas I and II, their tautomers, stereoisomers and polymorphs, and pharmaceutically acceptable salts, esters, metabolites or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the inhibition of Pim kinase activity and/or the prophylaxis or treatment of cancer.

PIM KINASE INHIBITORS AND METHODS OF THEIR USE

The present invention relates to new compounds of Formulas (I) and (II), their tautomers, stereoisomers and polymorphs, and pharmaceutically acceptable salts, esters, metabolites or prodrugs thereof, compositions of the new compounds together with pharmac