4442-91-5

Upstream product

• 108-94-1 cyclohexanone 
• 4484-35-9 3-cyclohexylacrylic acid 
• 2043-61-0 cyclohexanecarbaldehyde 

Downstream Products

• 872008-58-7 2-benzylamino-3-cyclohexyl-3-hydroxypropionic acid 
• 101972-56-9 (2S,3S)-3-Cyclohexyl-2-hydroxy-butyric acid 
• 101972-51-4 anti-3-cyclohexyl-3-hydroxy-2-methylpropanoic acid 
• 101972-73-0 (2S,3S)-2-Acetoxy-3-cyclohexyl-butyric acid methyl ester 
• 101972-69-4 (2S,3S)-3-Acetoxy-3-cyclohexyl-2-methyl-propionic acid methyl ester 

Relevant academic research and scientific papers

Methods for producing D-beta-hydroxyamino acids

An objective of the present invention is to provide efficient methods for producing D-β-hydroxyamino acids (formula 2 or 4), such as D-erythro-2-amino-3-cyclohexyl-3-hydroxypropionic acid, which are useful as intermediates in the synthesis of pharmaceutical products and others. The present invention makes it possible to efficiently produce D-erythro-2-amino-3-cyclohexyl-3-hydroxypropionic acid by cleaving unnecessary L-erythro-2-amino-3-cyclohexyl-3-hydroxypropionic acid in industrially feasible concentrations of DL-erythro-2-amino-3-cyclohexyl-3-hydroxypropionic acid used as starting material by using Pseudomonas putida-derived L-phenylserine aldolase.

Carboxylate-stabilised sulfur ylides (thetin salts) in asymmetric epoxidation for the synthesis of glycidic acids. Mechanism and implications

The reaction of carboxylate-stabilised sulfur ylides (thetin salts) with aldehydes and ketones has been investigated. Using both achiral and chiral sulfur ylides, good yields were obtained with dimsylsodium or LHMDS as bases in DMSO or THF-DMSO mixtures.