444663-45-0

Usage

Chemical class

Benzenepropanoic acids

Derivative

Benzoic acid

Bromine atoms

Attached at the 2 and 6 positions

Methoxy group

At the 4 position of the benzene ring

Propanoic acid group

Attached to the benzene ring

Applications

Pharmaceutical and chemical synthesis

Properties

Anti-inflammatory and analgesic effects

Safety precautions

Handle with caution and follow proper safety measures due to potential hazards

Upstream product

• 130445-13-5 1,3-dibromo-2-(bromomethyl)-5-methoxybenzene 
• 14542-71-3 2,6-dibromo-4-methoxytoluene 
• 444663-44-9 t-butyl 3-(2,6-dibromo-4-methoxyphenyl)-propionate 

Downstream Products

• 444663-46-1 N-(2,6-dichlorophenyl)-3-(2,6-dibromo-4-methoxyphenyl)-propionamide 
• 444663-63-2 7-(1-tert-butoxycarbonyl-1,2,3,6-tetrahydro-4-pyridinyl)-5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-3,4-dihydro-2(1H)-quinolinone 
• 444665-24-1 tert-Butyl 4-[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2-dihydroquinolin-7-yl]piperidine-1-carboxylate 
• 444665-23-0 tert-butyl 4-[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2-dihydroquinolin-7-yl]-3,6-dihydropyridine-1(2 H)-carboxylate 
• 444663-62-1 trifluoro-methanesulfonic acid 5-(2-chloro-4-fluoro-phenyl)-1-(2,6-dichloro-phenyl)-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl ester 
• 444660-11-1 5-(2-Chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-3,4-dihydro-7-(4-piperidinyl)-2(1H)-quinolinone 
• 444665-25-2 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-piperidin-4-ylquinolin-2(1H)-one 
• 444663-61-0 5-(2-chloro-4-fluoro-phenyl)-1-(2,6-dichloro-phenyl)-7-hydroxy-3,4-dihydro-1H-quinolin-2-one 
• 444663-60-9 5-(2-chloro-4-fluoro-phenyl)-1-(2,6-dichloro-phenyl)-7-methoxy-3,4-dihydro-1H-quinolin-2-one 
• 444663-58-5 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-methoxy-2(1H)-quinolinone 
• 444663-59-6 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-hydroxy-2(1H)-quinolinone 
• 444663-43-8 5-bromo-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone 
• 527680-10-0 5-bromo-1-(2,6-dichloro-phenyl)-7-methoxy-1H-quinolin-2-one 

Relevant academic research and scientific papers

p38 inhibitors: Piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones

We have synthesized a series of C7-piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones that are highly potent inhibitors of both p38 MAP kinase activity and TNF-α release. The 4-aminopentamethylpiperidin

(Halo-benzo carbonyl)heterocyclo fused phenyl p38 kinase inhibiting agents

Compounds described by the chemical formula (I) or a pharmaceutically acceptable salt thereof: are inhibitors of p38 useful in the treatment of inflammatory diseases such as arthritis.