444663-58-5Relevant academic research and scientific papers
Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors
Chen, Meng-Hsin,Fitzgerald, Patricia,Singh, Suresh B.,O'Neill, Edward A.,Schwartz, Cheryl D.,Thompson, Chris M.,O'Keefe, Stephen J.,Zaller, Dennis M.,Doherty, James B.
, p. 2222 - 2226 (2008/09/20)
Synthesis and biological activities of some quinolinone and dihydroquinolinone p38 MAP kinase inhibitors are reported. Modifications to the dihydroquinolinone pharmacophore revealed that dihydroquinolinone may be replaced with a quinolinone pharmacophore
p38 inhibitors: Piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones
Hunt, Julianne A.,Kallashi, Florida,Ruzek, Rowena D.,Sinclair, Peter J.,Ita, Ida,McCormick, Sherrie X.,Pivnichny, James V.,Hop, Cornelis E. C. A.,Kumar, Sanjeev,Wang, Zhen,O'Keefe, Stephen J.,O'Neill, Edward A.,Porter, Gene,Thompson, James E.,Woods, Andrea,Zaller, Dennis M.,Doherty, James B.
, p. 467 - 470 (2007/10/03)
We have synthesized a series of C7-piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones that are highly potent inhibitors of both p38 MAP kinase activity and TNF-α release. The 4-aminopentamethylpiperidin
(Halo-benzo carbonyl)heterocyclo fused phenyl p38 kinase inhibiting agents
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, (2008/06/13)
Compounds described by the chemical formula (I) or a pharmaceutically acceptable salt thereof: are inhibitors of p38 useful in the treatment of inflammatory diseases such as arthritis.
