444806-77-3

Upstream product

• 438528-25-7 (R)-(-)-2-azido-1-(4-tert-butyldimethylsilyloxyphenyl)ethanol 
• 459867-22-2 1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-nitro-ethanol 
• 120743-99-9 p-[(tert-butyldimethylsilyl)oxy]benzaldehyde 

Downstream Products

• 444806-78-4 1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[2-(3,4-dimethoxy-phenyl)-ethylamino]-ethanol 
• 71771-90-9 denopamine 
• 459867-19-7 N-{2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-ethyl}-2-(3,4-dimethoxy-phenyl)-acetamide 

Relevant academic research and scientific papers

Stereoselective synthesis of (R)-(-)-denopamine, (R)-(-)-tembamide and (R)-(-)-aegeline via asymmetric reduction of azidoketones by Daucus carota in aqueous medium

A simple and efficient stereoselective synthesis of (R)-denopamine and other naturally occurring hydroxy amides from optically active (R)-2-azido-1-arylethanols, is described for the first time via reduction of the corresponding α-azidoarylketones with en

Effect of ligand structure on the zinc-catalyzed Henry reaction. Asymmetric syntheses of (-)-denopamine and (-)-arbutamine

(Matrix presented) Syntheses of variously modified ligands for the dinuclear zinc catalysts for the asymmetric aldol and nitroaldol (Henry) reactions are reported. Catalytic enantioselective nitroaldol reactions promoted by these modified ligands led to efficient syntheses of the β-preceptor agonists (-)-denopamine and (-)-arbutamine.