444807-47-0

Basic information

• Product Name: Methyl 2-(4-cyanophenyl)-2-methylpropanoate
• Synonyms: Methyl 2-(4-cyanophenyl)-2-methylpropanoate
• CAS NO: 444807-47-0
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.23712
• Mol File: 444807-47-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 2-(4-cyanophenyl)-2-methylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(4-cyanophenyl)-2-methylpropanoate(444807-47-0)
• EPA Substance Registry System: Methyl 2-(4-cyanophenyl)-2-methylpropanoate(444807-47-0)

Safety Data

• Hazardous Substances Data: 444807-47-0(Hazardous Substances Data)

Upstream product

• 4648-54-8 trimethylsilylazide 
• 19956-03-7 2-(4-cyanophenyl)propene 
• 35733-58-5 tetra(n-butyl)ammonium formate 
• 547-63-7 Methyl isobutyrate 
• 623-00-7 4-bromobenzenecarbonitrile 
• 23426-63-3 2-bromo-2-methylpropionic acid methyl ester 
• 52798-01-3 methyl 4-cyanobenzeneacetate 
• 74-88-4 methyl iodide 
• 557-21-1 dicyanozinc 
• 154825-97-5 methyl 2-(4-bromophenyl)-2,2-dimethylacetate 
• 77802-22-3 4-(2-hydroxypropan-2-yl)benzenecarbonitrile 

Downstream Products

• 1000804-51-2 C₁₁H₁₁NO₂ 
• 223513-83-5 2-(4-aminomethyl-phenyl)-2-methylpropionic acid methyl ester 

Relevant articles and documents

Boryl Radical Activation of Benzylic C-OH Bond: Cross-Electrophile Coupling of Free Alcohols and CO2via Photoredox Catalysis

A new strategy for the direct cleavage of the C(sp3)-OH bond has been developed via activation of free alcohols with neutral diphenyl boryl radical generated from sodium tetraphenylborate under mild visible light photoredox conditions. This strategy has been verified by cross-electrophile coupling of free alcohols and carbon dioxide for the synthesis of carboxylic acids. Direct transformation of a range of primary, secondary, and tertiary benzyl alcohols to acids has been achieved. Control experiments and computational studies indicate that activation of alcohols with neutral boryl radical undergoes homolysis of the C(sp3)-OH bond, generating alkyl radicals. After reducing the alkyl radical into carbon anion under photoredox conditions, the following carboxylation with CO2 affords the coupling product.

Palladium-catalyzed α-arylation of zinc enolates of esters: Reaction conditions and substrate scope

The intermolecular α-arylation of esters by palladium-catalyzed coupling of aryl bromides with zinc enolates of esters is reported. Reactions of three different types of zinc enolates have been developed. α-Arylation of esters occurs in high yields with i

FUROISOQUINOLINE DERIVATIVE AND USE THEREOF

The present invention provides a compound represented by the formula ???wherein A represents (1) a bond, (2) a group represented by the formula -CRa=CRb- (Ra and Rb each represent a hydrogen atom or C1-6 alkyl) and the like; R1 represents (1) cyano or (2) an optionally esterified or amidated carboxyl group; R2 represents(1) a hydrogen atom, (2) an optionally substituted hydroxy group,(3) an optionally substituted amino group and the like; R3 and R4 each represent a hydrogen atom and the like; R5 represents a hydrogen atom and the like; R6 represents an optionally substituted hydroxy group and the like; R7and R8 each represent an optionally substituted hydrocarbon group and the like; R9 and R10 each represent (1) a hydrogen atom and the like; Y represents an optionally substituted methylene group; and n represents 0 or 1, or a salt thereof, which has an excellent phosphodiesterase IV inhibiting action.