444816-18-6Relevant academic research and scientific papers
Facile cleavage of triethylsilyl (TES) ethers using o-lodoxybenzoic acid (IBX) without affecting tert-butyldimethylsilyl (TBS) ethers
Wu, Yikang,Huang, Jia-Hui,Shen, Xin,Hu, Qi,Tang, Chao-Jun,Li, Liang
, p. 2141 - 2144 (2007/10/03)
(matrix presented) In DMSO cleavage of triethylsilyl (TES) ethers by o-iodoxybenzoic acid (IBX) was significantly faster than cleavage of tert-butyldimethylsilyl (TBS) ethers or further oxidation into carbonyl compounds. In most cases, TES protecting groups be removed in good to excellent yields within 1 h, whereas similar TBS protecting groups remained intact under the same conditions. The procedure also could be adapted for direct one-pot conversion of TES ethers into carbonyl compounds.
