444894-57-9Relevant academic research and scientific papers
Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands
Hong, Qingmei,Bakshi, Raman K.,Dellureficio, James,He, Shuwen,Ye, Zhixiong,Dobbelaar, Peter H.,Sebhat, Iyassu K.,Guo, Liangqin,Liu, Jian,Jian, Tianying,Tang, Rui,Kalyani, Rubana N.,MacNeil, Tanya,Vongs, Aurawan,Rosenblum, Charles I.,Weinberg, David H.,Peng, Qingping,Tamvakopoulos, Constantin,Miller, Randy R.,Stearns, Ralph A.,Cashen, Doreen,Martin, Willian J.,Chen, Airu S.,Metzger, Joseph M.,Chen, Howard Y.,Strack, Allison M.,Fong, Tung M.,MacLntyre, Euan,Van Der Ploeg, Lex H.T.,Wyvratt, Matthew J.,Nargund, Ravi P.
scheme or table, p. 4483 - 4486 (2010/10/02)
Design, syntheses and structure-activity relationships of N-acetylated piperazine privileged structures containing MC4R agonist compounds were described. The most potent derivatives were low nM MC4R selective full agonists. Several compounds from the series had modest pharmacokinetic properties.
