444893-46-3

Basic information

• Product Name: tert-butyl 4-(2-amino-1-cyclohexylethyl)piperazine-1-carboxylate
• Synonyms: tert-butyl 4-(2-amino-1-cyclohexylethyl)piperazine-1-carboxylate
• CAS NO: 444893-46-3
• Molecular Weight: 311.468
• Mol File: 444893-46-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(2-amino-1-cyclohexylethyl)piperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(2-amino-1-cyclohexylethyl)piperazine-1-carboxylate(444893-46-3)
• EPA Substance Registry System: tert-butyl 4-(2-amino-1-cyclohexylethyl)piperazine-1-carboxylate(444893-46-3)

Safety Data

• Hazardous Substances Data: 444893-46-3(Hazardous Substances Data)

Upstream product

• 444896-37-1 4-[1-cyclohexyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 23860-35-7 cyclohexylacetic acid chloride 
• 58851-63-1 Brom-cyclohexylessigsaeure-methylester 
• 90085-61-3 2-bromocyclohexylacetylchloride 
• 444893-42-9 4-(1-cyclohexyl-2-hydroxy-ethyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 5292-21-7 Cyclohexylacetic acid 
• 444893-16-7 4-(cyclohexyl-methoxycarbonyl-methyl)-piperazine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 444896-36-0 4-(1-cyclohexyl-2-methanesulfonylamino-ethyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 779318-92-2 N-(2-cyclohexyl-2-piperazin-1-yl-ethyl)-methanesulfonamide 
• 727974-08-5 N-(2-cyclohexyl-2-piperazin-1-yl-ethyl)-N-ethyl-acetamide 
• 786635-59-4 N-(2-cyclohexyl-2-piperazin-1-yl-ethyl)-N-ethyl-methanesulfonamide 
• 444893-53-2 4-(1-cyclohexyl-2-ethylamino-ethyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 444896-45-1 4-[2-(acetyl-ethyl-amino)-1-cyclohexyl-ethyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 444896-38-2 4-[1-cyclohexyl-2-(ethyl-methanesulfonyl-amino)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 900535-66-2 1-({1-(4-chloro-benzyl)-2-[4-(1-cyclohexyl-2-methanesulfonylamino-ethyl)-piperazin-1-yl]-2-oxo-ethylcarbamoyl}-methyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 900535-68-4 1-{[2-{4-[2-(acetyl-ethyl-amino)-1-cyclohexyl-ethyl]-piperazin-1-yl}-1-(4-chloro-benzyl)-2-oxo-ethylcarbamoyl]-methyl}-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 900535-67-3 1-[(1-(4-chloro-benzyl)-2-{4-[1-cyclohexyl-2-(ethyl-methanesulfonyl-amino)-ethyl]-piperazin-1-yl}-2-oxo-ethylcarbamoyl)-methyl]-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 757245-79-7 C₂₅H₄₉N₃O₂ 
• 444894-57-9 C₂₁H₄₁N₃O₂ 
• 757245-81-1 C₂₀H₃₉N₃O₂ 
• 444896-34-8 4-(1-cyclohexyl-2-diethylamino-ethyl)-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Privileged structure based ligands for melanocortin-4 receptors-Aliphatic piperazine derivatives

Aliphatic carbocyclic replacement of the benzyl group of compound 1 yielded compounds with high affinity for the melanocortin-4 receptor (MC4R). Compounds with a cyclohexyl group showed a consistent high affinity, while different polar groups with less basicity were good replacements for the original diethyl amines. Substitution of the polar group found in these privileged structures with an aliphatic moiety produced compounds with high affinity for MC4R.