444901-94-4

Upstream product

• 41324-66-7 H-Pro-OBzl 
• 1079-66-9 chloro-diphenylphosphine 

Downstream Products

• 444901-96-6 (R)-{[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-phenyl-acetic acid methyl ester 
• 444901-95-5 (R)-2-{[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyric acid methyl ester 
• 444901-98-8 (R)-2-[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidin-2-yl]-4-phenyl-4,5-dihydro-oxazole 
• 608533-93-3 (S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carboxylic acid ((R)-1-hydroxymethyl-2-methyl-propyl)-amide 
• 444901-97-7 (R)-2-[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidin-2-yl]-4-isopropyl-4,5-dihydro-oxazole 
• 666723-36-0 (R)-2-{[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-3,3-dimethyl-butyric acid 
• 666727-83-9 (R)-4-tert-Butyl-2-[(S)-1-(diphenyl-phosphinothioyl)-pyrrolidin-2-yl]-4,5-dihydro-oxazole 
• 61057-98-5 (S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carboxylic acid 

Relevant academic research and scientific papers

Asymmetric hydrogenation of aromatic olefins catalyzed by iridium complexes of proline derived phosphine-oxazoline ligands

The synthesis of a series of phosphine-oxazoline ligands is reported. This ligands are synthesized by reaction of a phosphine chloride with the secondary nitrogen of proline. Upon coordination to iridium the resulting complexes can be used in the asymmetric hydrogenation of simple olefins. The effect of different counter ions and substitution at the oxazoline and the phosphine is reported.

Facile synthesis of proline based phosphine-oxazoline ligands by formation of a P-N bond

A series of new P-N ligands in which the phosphorus moiety is introduced by formation of a phosphorus-heteroatom bond are synthesized. These ligands are based on proline with chiral centers from both proline and an oxazoline. The two chiral centers are re