444901-97-7

Upstream product

• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 4070-48-8 D-Valine methyl ester 
• 282088-13-5 (S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 608533-81-9 diphenylphosphine proline methyl ester 
• 1079-66-9 chloro-diphenylphosphine 
• 61057-98-5 (S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carboxylic acid 
• 608533-93-3 (S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carboxylic acid ((R)-1-hydroxymethyl-2-methyl-propyl)-amide 
• 41324-66-7 H-Pro-OBzl 
• 444901-95-5 (R)-2-{[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyric acid methyl ester 
• 444901-94-4 (S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Two-fold amino acid-based chiral aminophosphine-oxazolines and use in asymmetric allylic alkylation

Chiral aminophosphine-oxazoline ligands derived from two different amino acids (tetrahydroisoquinoline carboxylic acid and proline) have been synthesized and examined as chiral auxiliaries in asymmetric allylic alkylation of three substrates. Stereoisomers 1a and 2a are providing the highest enantioselectivities (up to 94% ee) in the allylation of diphenylpropenyl acetate.

Facile synthesis of proline based phosphine-oxazoline ligands by formation of a P-N bond

A series of new P-N ligands in which the phosphorus moiety is introduced by formation of a phosphorus-heteroatom bond are synthesized. These ligands are based on proline with chiral centers from both proline and an oxazoline. The two chiral centers are re