444902-32-3

Basic information

• Product Name: 3-PYRIDINAMINE, 6-CHLORO-5-IODO-
• Synonyms: 3-PYRIDINAMINE, 6-CHLORO-5-IODO-;5-Amino-2-chloro-3-iodopyridine;6-Chloro-5-iodo-pyridin-3-ylaMine;6-chloro-5-iodopyridin-3-aMine
• CAS NO: 444902-32-3
• Molecular Formula: C5H4ClIN2
• Molecular Weight: 254.454
• Product Categories: amine| alkyl chloride| alkyl Iodine
• Mol File: 444902-32-3.mol

Chemical Properties

• Melting Point: 115-125°C
• Boiling Point: 384.3 °C at 760 mmHg
• Flash Point: 186.2 °C
• Appearance: /
• Density: 2.139 g/cm³
• PKA: 0.97±0.10(Predicted)
• CAS DataBase Reference: 3-PYRIDINAMINE, 6-CHLORO-5-IODO-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PYRIDINAMINE, 6-CHLORO-5-IODO-(444902-32-3)
• EPA Substance Registry System: 3-PYRIDINAMINE, 6-CHLORO-5-IODO-(444902-32-3)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-41-50
• Safety Statements: 26-39-61
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 2
• Hazardous Substances Data: 444902-32-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Pyridinamine, 6-chloro-5-iodois used as a building block for the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications. The presence of both chlorine and iodine atoms in the molecule can be exploited to create novel drug candidates with improved pharmacological properties, such as enhanced solubility, bioavailability, and target selectivity.
Used in Agrochemical Industry:
3-Pyridinamine, 6-chloro-5-iodois also used as a building block for the synthesis of agrochemicals, including pesticides and herbicides. Its unique structure can contribute to the development of new agrochemicals with improved efficacy, selectivity, and environmental compatibility. The presence of halogen atoms can enhance the lipophilicity and volatility of the resulting agrochemicals, potentially improving their performance in agricultural applications.
Used in Organic Synthesis:
3-Pyridinamine, 6-chloro-5-iodois used as a versatile reagent in organic synthesis. Its unique structure allows for various chemical reactions, such as nucleophilic substitution, electrophilic substitution, and cross-coupling reactions, to be performed. This enables the synthesis of a wide range of chemical products, including complex organic molecules, heterocycles, and functionalized materials.
Used in Academic Research:
3-Pyridinamine, 6-chloro-5-iodoserves as a valuable research tool in academic laboratories. Its unique structure and properties make it an interesting subject for studying various aspects of chemistry, such as reaction mechanisms, synthetic methodologies, and structure-activity relationships. Additionally, it can be used to explore the potential applications of pyridine derivatives in various fields, including materials science, catalysis, and supramolecular chemistry.

Upstream product

• 25391-60-0 2-chloro-3-iodo-5-nitropyridine 
• 5418-51-9 5-nitro-2-hydroxypyridine 
• 25391-58-6 2-hydroxy-3-iodo-5-nitropyridine 
• 7439-89-6 iron 

Downstream Products

• 444902-34-5 2-chloro-5-hydroxy-3-iodopyridine 

Relevant articles and documents

Synthesis and in-vivo evaluation of [11C]p-PVP-MEMA as a PET radioligand for imaging nicotinic receptors

Within the class of (4-pyridinyl)vinylpyridines developed by Abbott laboratories as potent neuronal nicotinic acetylcholine receptor ligands, p-PVP-MEMA ({(R)-2-[6-chloro-5-((E)-2-pyridin-4-ylvinyl)pyridin-3-yloxy]-1- methylethyl}methylamine) is the lead compound of a novel series that do not display the traditional nicotinic-like pyrrole-ring but still possessing high subnanomolar affinity (Ki 0.077 nm?displacement of [ 3H](?)cytisine from whole rat brain synaptic membranes). In the present study, p-PVP-MEMA and its nor-derivative ({(R)-2-[6-chloro-5-((E)-2- pyridin-4-ylvinyl)pyridin-3-yloxy]-1-methylethyl}methylamine) as precursor for labelling with the short-lived positron-emitter carbon-11 (T1/2 20.4 min) were synthesized in 10 chemical steps from 2-hydroxy-5-nitropyridine and Boc-d-alanine. N-Alkylation of nor-p-PVP-MEMA with [11C]methyl iodide afforded [11C]p-PVP-MEMA (>98% radiochemically pure, specific activity of 86.4 GBq ?mol?1) in 2% (non-decay corrected and non-optimized) radiochemical yield, in 34 min (including HPLC purification and formulation). Preliminary positron emission tomography (PET) results obtained in a Papio hamadryas baboon showed that [11C]p-PVP-MEMA is not a suitable PET-radioligand. CSIRO 2008.

ORGANIC COMPOUNDS

The present invention relates to quinazolinone compounds of the formula wherein R2, R3, R5, R6 R7 and R8 are as defined in the specification and in the claims, in free form or in salt form , processes for their preparation and their use as pharmaceuticals, particularly in the treatment of disorders ameliorated by administration of TRPV1 antagonists.

Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

Synthesis and evaluation of a novel series of 2-chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)- 3-(2-(4-pyridinyl)vinyl)pyridine analogues as potential positron emission tomography imaging agents for nicotinic acetylcholine receptors

Reportedly, 2-[18F]fluoro-A-85380, 1, a promising radiotracer for imaging the nicotinic acetylcholine receptor (nAChR) by positron emission tomography (PET) in humans, exhibits slow penetration through the blood-brain barrier (BBB) due to its low lipophilicity. A ligand for nAChRs with greater lipophilicity than that of 1 would be potentially more favorable for PET imaging of nAChR due to its faster penetration through the BBB. Herein, a novel series of compounds has been developed based on the high affinity ligand for nAChRs, 2-chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)- 3-(2-(4-pyridinyl)vinyl)pyridine, 3b. The in vitro binding affinities for the new series were found to be in the range of Ki = 9-331 pM. A molecular modeling study showed differences in the comformational profiles and the electronic properties of these compounds, which provides further insight into the structure-activity relationships at nAChR. Lipophilicities of the compounds 3b-6b have been found to be substantially higher than that of 1. As a result, compounds 3b-6b might exhibit a faster penetration through the BBB than the less lipophilic 1. The N-methyl derivatives 3b and 6b demonstrated very high affinities at nAChRs (Ki = 28 and 23 pM, respectively) and will be targets for development of 11CH3-labeled derivatives as radiotracers for PET imaging of nAChRs.