445029-32-3 Usage
Uses
Used in Pharmaceutical Industry:
2-(4-TERT-BUTYL-PHENYL)-CYCLOPROPANECARBOXYLIC ACID is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical industry, 2-(4-TERT-BUTYL-PHENYL)-CYCLOPROPANECARBOXYLIC ACID is used as a building block for the creation of novel agrochemicals, potentially enhancing crop protection and yield.
Used as a Potent Inhibitor of 11β-HSD1:
2-(4-TERT-BUTYL-PHENYL)-CYCLOPROPANECARBOXYLIC ACID acts as a potent inhibitor of 11β-HSD1, an enzyme involved in the metabolism of glucocorticoids. This makes it a promising candidate for the treatment of metabolic disorders such as diabetes and obesity.
Used in Anti-Inflammatory and Analgesic Applications:
Due to its anti-inflammatory and analgesic properties, 2-(4-TERT-BUTYL-PHENYL)-CYCLOPROPANECARBOXYLIC ACID is being studied for its potential use in the development of new drugs to treat pain and inflammation-related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 445029-32-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,5,0,2 and 9 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 445029-32:
(8*4)+(7*4)+(6*5)+(5*0)+(4*2)+(3*9)+(2*3)+(1*2)=133
133 % 10 = 3
So 445029-32-3 is a valid CAS Registry Number.
445029-32-3Relevant academic research and scientific papers
Design, synthesis and biological evaluation of B-region modified diarylalkyl amide analogues as novel TRPV1 antagonists
Han, Young Taek,Yang, Shao-Mei,Wang, Xiao-Yuan,Li, Fu-Nan
, p. 440 - 451 (2014/04/17)
Design, synthesis and biological evaluation of B-region, known to be a dipolar interacting pharmacophore, modified diarylalkyl amide analogues for novel TRPV1 (transient receptor potential channel, vanilloid subfamily member 1) antagonists was described. A variety of moieties including guanidines, heterocyclic rings, cinnamides, and α-substituted acetamides were introduced at the B-region. TRPV1 antagonistic activities of these analogues were evaluated by 45Ca2+ uptake assay in rat DRG neuron. In particular, α,α-difluoroamide 53 exhibited 3-fold more potent TRPV1 antagonistic activity (IC50 = 0.058 μM) than the parent amide analogue 6.
NOVEL COMPOUNDS, ISOMER THEREOF OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
-
Page/Page column 55-56, (2010/11/23)
This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1 )antagonist; and a pharmaceutical composition containing the same. The present invention
