445029-32-3 Usage
General Description
2-(4-tert-butyl-phenyl)-cyclopropanecarboxylic acid is a chemical compound with the molecular formula C15H20O2. It is a cyclopropylcarboxylic acid derivative, and the tert-butyl and phenyl groups confer steric hindrance and hydrophobic properties. 2-(4-TERT-BUTYL-PHENYL)-CYCLOPROPANECARBOXYLIC ACID is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It acts as a potent inhibitor of 11β-HSD1, an enzyme involved in the metabolism of glucocorticoids, and has potential applications in the treatment of metabolic disorders, such as diabetes and obesity. Additionally, it has been studied for its anti-inflammatory and analgesic properties, making it a promising candidate for the development of new drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 445029-32-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,5,0,2 and 9 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 445029-32:
(8*4)+(7*4)+(6*5)+(5*0)+(4*2)+(3*9)+(2*3)+(1*2)=133
133 % 10 = 3
So 445029-32-3 is a valid CAS Registry Number.
445029-32-3Relevant articles and documents
Design, synthesis and biological evaluation of B-region modified diarylalkyl amide analogues as novel TRPV1 antagonists
Han, Young Taek,Yang, Shao-Mei,Wang, Xiao-Yuan,Li, Fu-Nan
, p. 440 - 451 (2014/04/17)
Design, synthesis and biological evaluation of B-region, known to be a dipolar interacting pharmacophore, modified diarylalkyl amide analogues for novel TRPV1 (transient receptor potential channel, vanilloid subfamily member 1) antagonists was described. A variety of moieties including guanidines, heterocyclic rings, cinnamides, and α-substituted acetamides were introduced at the B-region. TRPV1 antagonistic activities of these analogues were evaluated by 45Ca2+ uptake assay in rat DRG neuron. In particular, α,α-difluoroamide 53 exhibited 3-fold more potent TRPV1 antagonistic activity (IC50 = 0.058 μM) than the parent amide analogue 6.
Tertiary amine compounds
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, (2008/06/13)
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