445390-06-7Relevant academic research and scientific papers
Metal complexes with biological important ligands. CXLII. Half sandwich complexes of ruthenium(II), rhodium(III), and iridium(III) with tripeptide esters from α-, β-, and γ-amino acids as ligands. - Peptide synthesis and cyclization to cyclotripeptides at metal centers
Haas, Katharina,Beck, Wolfgang
, p. 788 - 796 (2002)
Halfsandwich complexes of ruthenium, rhodium and iridium with deprotonated N,N′,N″-tripeptide ester ligands were obtained from chloro bridged compounds and tripeptide methyl esters (1-6) or by peptide synthesis at a metal centre (9-15). For the peptide synthesis at the complex (C6Me6)Ru coordinated dipeptide methyl esters from glycine and β-alanine or γ-amino butyric acid were elongated by an α-amino acid methylester. The tripeptide ester Ru(η6-C6Me6) complexes with chiral amino acid components and an asymmetric metal atom are formed with high diastereoselectivity. The tripeptide esters Gly-Gly-β-AlaOMe, Val-Gly-β-AlaOMe and Phe-Gly-β-AlaOMe can be condensated at the (C6Me6)Ru complex with sodium methanolate to give triple deprotonated cyclic tripeptides.
