4454-63-1

Usage

Uses

Used in Agricultural Industry:
2-Chloro-N-1,3,4-thiadiazol-2-ylacetamide is used as a fungicide and bactericide for controlling harmful organisms in crops, thereby enhancing crop health and productivity.
Used in Pharmaceutical Industry:
It is utilized in the synthesis of pharmaceuticals, where its unique chemical structure and properties contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
2-Chloro-N-1,3,4-thiadiazol-2-ylacetamide is employed in the production of agrochemicals, which are essential for protecting crops from diseases and pests, ensuring a stable food supply.
Used in Organic Compounds Synthesis:
2-CHLORO-N-1,3,4-THIADIAZOL-2-YLACETAMIDE is used as a key intermediate in the synthesis of various organic compounds, expanding its applications in the field of organic chemistry.
Used in Material Science:
Due to its unique chemical structure and properties, 2-Chloro-N-1,3,4-thiadiazol-2-ylacetamide has potential applications in the development of new materials and products, contributing to advancements in material science.

InChI:InChI=1/C4H4ClN3OS/c5-1-3(9)7-4-8-6-2-10-4/h2H,1H2,(H,7,8,9)

Upstream product

• 4005-51-0 [1,3,4]Thiadiazol-2-ylamin 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 57632-93-6 o-tolyl-dithiocarbamic acid [1,3,4]thiadiazol-2-ylcarbamoyl-methyl ester 
• 57632-95-8 p-tolyl-dithiocarbamic acid [1,3,4]thiadiazol-2-ylcarbamoyl-methyl ester 
• 57632-96-9 (4-chloro-phenyl)-dithiocarbamic acid [1,3,4]thiadiazol-2-ylcarbamoyl-methyl ester 
• 57632-92-5 phenyl-dithiocarbamic acid [1,3,4]thiadiazol-2-ylcarbamoyl-methyl ester 
• 57632-94-7 m-tolyl-dithiocarbamic acid [1,3,4]thiadiazol-2-ylcarbamoyl-methyl ester 
• 885430-27-3 2-(4-phenylpiperazin-1-yl)-N-(1,3,4-thiadiazol-2-yl)acetamide 
• 24535-63-5 4-methyl-N-(thiazol-2-ylcarbamoyl)benzenesulfonamide 

Relevant academic research and scientific papers

Thiadiazole thiazolinone compounds, and preparation method and application thereof

The invention discloses thiadiazole thiazolinone compounds. The thiadiazole thiazolinone compounds have a chemical structure as shown in a formula which is described in the specification. In the formula, R is selected from the group consisting of chemical groups which are described in the specification. The preparation method comprises the following steps: with thiosemicarbazide as a raw material,carrying out cyclodehydration with formic acid under the catalytic condition of concentrated sulfuric acid so as to synthesize a first intermediate product, then carrying out synthesizing with chloroacetyl chloride so as to obtain a second intermediate product, carrying out cyclization under the action of ammonium thiocyanate so as to synthesize a third intermediate product, and allowing a thirdcompound to react with R1 through a Knoevenagle condensation reaction so as to obtain the thiadiazole thiazolinone compounds. According to the invention, by utilization of an active structure splicingprinciple, bis-heterocyclic compounds with a thiazole ring and thiazolinone are synthesized through structure splicing of 1,3,4-thiadiazole and 4-thiazolinone, so bis-heterocyclic pesticide derivatives with excellent activity are obtained; a novel green pesticide variety with high activity, low toxicity and less pollution is selected; and the thiadiazole thiazolinone compounds can be applied to bactericides or pesticides.

Synthesis, antioxidant, and antitumor evaluation of certain new N-substituted-2-amino-1,3,4-thiadiazoles

Reaction of 2-amino-1,3,4-thiadiazole (1) with chloroacetyl chloride afforded the chloroacetamide 2 which used as starting compound for the synthesis of 2-thiocyanatoacetamide 3 and N-(1,3,4-thiadiazol-2-yl)acetamides 5-9 via reaction of 1 with various re

Synthesis and antifungal activity of thiadiazole-functionalized chitosan derivatives

A groups of novel water soluble chitosan derivatives containing 1,3,4-thiadiazole group were synthesized including 1,3,4-thiadiazole (TPCTS), 2-methyl-1,3,4-thiadiazole (MTPCTS), and 2-phenyl-1,3,4-thiadiazole (PTPCTS). Their antifungal activity against three kinds of phytopathogens was estimated by hypha measurement in vitro, and the fungicidal assessment shows that the synthesized chitosan derivatives have excellent activity against tested fungi. Of all the synthesized chitosan derivatives, MTPCTS inhibited the growth of the tested phytopathogens most effectively with inhibitory indices of 75.3%, 82.5%, and 65.8% against Colletotrichum lagenarium (Pass) Ell.et halst, Phomopsis asparagi (Sacc.) Bubak, and Monilinia fructicola (Wint.) Honey respectively at 1.0 mg/mL. These indices are higher than those of chitosan. These data also demonstrate that the hydrophobic moiety (alkyl and phenyl) and the length of alkyl substituent in thiadiazole tend to affect the antifungal activity of chitosan derivatives. It is hypothesized that thiadiazole groups enable the synthesized chitosan to possess obviously better antifungal activity and good solubility in water.

Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7

Necroptosis is a regulated caspase-independent cell death mechanism characterized by morphological features resembling non-regulated necrosis. Necrotatin-7 (Nec-7), a novel potent small-molecule inhibitor of necroptosis, is structurally distinct from previously described necrostatins (Nec-1, Nec-3, Nec-4 and Nec-5). Here, we describe a series of structural modifications and the structure-activity relationship (SAR) of the Nec-7 series for inhibiting necroptosis.