2-CHLORO-N-1,3,4-THIADIAZOL-2-YLACETAMIDE

Base Information

• Chemical Name: 2-CHLORO-N-1,3,4-THIADIAZOL-2-YLACETAMIDE
• CAS No.: 4454-63-1
• Molecular Formula: C₄H₄ClN₃OS
• Molecular Weight: 177.614
• Hs Code.: 2934999090
• Mol file: 4454-63-1.mol

Synonyms:1,3,4-Thiadiazole,2-(2-chloroacetamido)- (7CI); NSC 297909

Chemical Property of 2-CHLORO-N-1,3,4-THIADIAZOL-2-YLACETAMIDE

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 83.12000
• Density: 1.617g/cm³
• LogP: 0.78840
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-N-(1,3,4-thiadiazol-2-yl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-N-1,3,4-THIADIAZOL-2-YLACETAMIDE

There total 2 articles about 2-CHLORO-N-1,3,4-THIADIAZOL-2-YLACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

[1,3,4]Thiadiazol-2-ylamin (4005-51-0) + chloroacetyl chloride (79-04-9) → 2-chloro-N-(1,3,4-thiadiazol-2-yl)acetamide (4454-63-1)

Guidance literature:

In 1,4-dioxane; for 5h; Reflux;

DOI:10.1007/s00044-012-0336-z

Reference yield:

→ 2-chloro-N-(1,3,4-thiadiazol-2-yl)acetamide (4454-63-1)

Guidance literature:

Aus 2-Amino-1,3,4-thiadiazol;

Reference yield: 70.0%

2-chloro-N-(1,3,4-thiadiazol-2-yl)acetamide (4454-63-1) + 4-phenyl-1-piperazine (92-54-6) → 2-(4-phenylpiperazin-1-yl)-N-(1,3,4-thiadiazol-2-yl)acetamide (885430-27-3)

Guidance literature:

With triethylamine; In 1,4-dioxane; for 2h; Reflux;

DOI:10.1007/s00044-012-0336-z

upstream raw materials:

[1,3,4]Thiadiazol-2-ylamin

chloroacetyl chloride

Downstream raw materials:

o-tolyl-dithiocarbamic acid [1,3,4]thiadiazol-2-ylcarbamoyl-methyl ester

p-tolyl-dithiocarbamic acid [1,3,4]thiadiazol-2-ylcarbamoyl-methyl ester

(4-chloro-phenyl)-dithiocarbamic acid [1,3,4]thiadiazol-2-ylcarbamoyl-methyl ester

phenyl-dithiocarbamic acid [1,3,4]thiadiazol-2-ylcarbamoyl-methyl ester

Refernces

• 1、 Hamama, Wafaa S.,Gouda, Moustafa A.,Badr, Marwa H.,Zoorob, Hanafi H.. "Synthesis, antioxidant, and antitumor evaluation of certain new N-substituted-2-amino-1,3,4-thiadiazoles". . p. 3556 - 3565. Retrieved 2013/07/26.
• 2、 Zheng, Weihong,Degterev, Alexei,Hsu, Emily,Yuan, Junying,Yuan, Chengye. "Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7". scheme or table. p. 4932 - 4935. Retrieved 2009/05/26.