445483-11-4

Upstream product

• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 215715-43-8 β,β-dibromo-3-isopropoxy-4-methoxystyrene 
• 34123-66-5 O-isopropylisovanillin 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 439585-86-1 4-ethynyl-2-isopropoxy-1-methoxybenzene 
• 621-59-0 isovanillin 

Downstream Products

• 939824-70-1 5-isopropoxy-2-(3-isopropoxy-4-methoxyphenyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)-1H-inden-1-one 
• 445483-12-5 2-(3-isopropoxy-4-methoxybenzylidene)-1,3-bis(3,4,5-trimethoxyphenyl)propane-1,3-dione 
• 445483-14-7 3-(3-isopropoxy-4-methoxyphenyl)-4,5,6-trimethoxy-2-(3,4,5-trimethoxybenzoyl)-1H-inden-1-one 
• 439585-92-9 2-(3′-isopropoxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole 

Relevant academic research and scientific papers

A 2-phenyl-substituted-3-benzoyl-substituted indole preparation method

The invention relates to a preparing method of 2-(phenyl-substituted)-3-(benzoyl-substituted)indole, and particularly discloses a preparing method of 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3'',4'',5''-triethoxybenzoyl)-6-methoxyindole (OXi8006). The structure formula of the OXi8006 is shown in the specification. The OXi8006 can generate good antitumor activity (IC50=1.1 muM) by inhibiting tubulin polymerization and is an important clinical candidate for treating tumor. Synthesis of the OXi8006 by the method has characteristics of simple conditions, easy operation, short reaction steps and high total yield.

The concise synthesis of chalcone, indanone and indenone analogues of combretastatin A4

A series of aryl- and aroyl-substituted chalcone analogues of the tubulin binding agent combretastatin A4 (1) were prepared, using a recently introduced one-pot palladium-mediated hydrostannylation-coupling reaction sequence. These chalcones were converte