4457-72-1

Basic information

• Product Name: 1,5-DIBROMO-3-METHYLPENTANE
• Synonyms: 1,5-DIBROMO-3-METHYLPENTANE;3-METHYL-1,5-DIBROMOPENTANE;1,5-Dibromo-3-methylpentane,98%;1,5-dibromo-3-methylenepentane
• CAS NO: 4457-72-1
• Molecular Formula: C₆H₁₂Br₂
• Molecular Weight: 243.97
• Mol File: 4457-72-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 233℃
• Flash Point: 101°(214°F)
• Appearance: Clear colourless liquid
• Density: 1.6
• Vapor Pressure: 0.0896mmHg at 25°C
• Refractive Index: 1.508-1.51
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: 1,5-DIBROMO-3-METHYLPENTANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-DIBROMO-3-METHYLPENTANE(4457-72-1)
• EPA Substance Registry System: 1,5-DIBROMO-3-METHYLPENTANE(4457-72-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25
• Hazardous Substances Data: 4457-72-1(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

1,5-Dibromo-3-methylpentane is used as a chemical reagent, pharmaceutical intermediate, pharmaceutical research.

InChI:InChI=1/C6H12Br2/c1-6(2-4-7)3-5-8/h6H,2-5H2,1H3

Upstream product

• 4457-71-0 3-methylpentane-1,5-diol 
• 17037-68-2 (4-methylpiperidin-1-yl)(phenyl)methanone 
• 4717-96-8 4-methyltetrahydropyran 
• 6829-42-1 diethyl 3-methylglutarate 
• 70928-41-5 5-methoxy-3-methyl-pentan-1-ol 
• 107-21-1 ethylene glycol 
• 4166-53-4 3-methylglutaric anhydride 
• 10138-44-0 2-ethoxy-4-methyl-3,4-dihydro-2H-pyran 
• 6280-15-5 3-methylpentanedial 

Downstream Products

• 10250-44-9 1-Brom-3-methyl-5-phthalimido-pentan 
• 5161-17-1 tetrahydro-4-methyl-2H-thiopyran 
• 54286-13-4 4-methyl-cyclohexane-1,1-dicarboxylic acid 
• 524048-18-8 4-methylcyclohexane-1-carbonitrile 
• 51174-46-0 3-methyl-1,5-diiodopentane 
• 139294-11-4 1,11-Ditosyloxy-2,6,10-trimethylundecane 
• 38451-99-9 5-Methylcyclooctanon 
• 123952-70-5 1,5-Diamino-3-methylpentane 
• 1419386-08-5 C₁₇H₂₂O₃ 
• 1119259-46-9 N-{(S)-6-[(R)-1-(4-Methylpiperidin-1-yl)ethyl]-1,2,3,4-tetrahydronaphthalen-2-yl}-4-[(S)-1-(tetrahydrofuran-2-yl)methoxy]benzamide 
• 1149748-48-0 C₁₂H₁₇BrO 
• 858677-84-6 1-[1-(4-iodo-phenyl)cyclopropyl]-4-methyl-piperidine 
• 868609-91-0 (R)-1'-(4-bromophenyl)-4-methyl-[1,3']-bipiperidinyl 

Relevant articles and documents

PHEROMONES OF INSECTS AND THEIR ANALOGS. XXIX. METHYL-BRANCHED PHEROMONES FROM 4-METHYLTETRAHYDROPYRAN. 4. SYNTHESIS OF (+/-)-15,19,23-TRIMETHYLHEPTATRIACONTANE - A PHEROMONE OF Glossina morsitans morsitans

Racemic 15,19,23-trimethylheptatriacontane (the sex pheromone of the tsetse fly Glossina morsitans morsitans) has been synthesized from 1,5-dibromo-3-methylpentane, a product of the acid hydrolysis of 4-methyltetrahydropyran.

Process intensification-assisted conversion of α,ω-alkanediols to dibromides

The increasingly widespread applications of α,ω-dibromides motivated development of a scalable, inexpensive process to rapidly convert selected α,ω-alkanediols to the corresponding dibromides. Diols were heated with only 48% aq HBr and an organic solvent, using a Dean-Stark apparatus modified to fractionate the azeotropic distillate, thereby maintaining a higher HBr concentration and reaction rate in the pot. Intensified distillation also increased the reaction rate. Various other substrate, solvent, and parameter effects have been discovered and rationalized.

Double-headed sulfur-linked amino acids as first inhibitors for betaine-homocysteine S -methyltransferase 2

Betaine-homocysteine S-methyltransferase 2 (BHMT-2) catalyzes the transfer of a methyl group from S-methylmethionine to l-homocysteine, yielding two molecules of l-methionine. It is one of three homocysteine methyltransferases in mammals, but its overall contribution to homocysteine remethylation and sulfur amino acid homeostasis is not known. Moreover, recombinant BHMT-2 is highly unstable, which has slowed research on its structural and catalytic properties. In this study, we have prepared the first series of BHMT-2 inhibitors to be described, and we have tested them with human recombinant BHMT-2 that has been stabilized by copurification with human recombinant BHMT. Among the compounds synthesized, (2S,8RS,11RS)-5-thia-2,11-diamino-8-methyldodecanedioic acid (11) was the most potent (Kiapp ～77 nM) and selective inhibitor of BHMT-2. Compound 11 only weakly inhibited human BHMT (IC 50 about 77 μM). This compound (11) may be useful in future in vivo studies to probe the physiological significance of BHMT-2 in sulfur amino acid metabolism.