446-18-4

Basic information

• Product Name: Benzenamine, 4-fluoro-2-methyl-5-nitro-
• Synonyms: Benzenamine, 4-fluoro-2-methyl-5-nitro-;4-Fluoro-2-methyl-5-nitroaniline;4-Fluoro-2-methyl-5-nitro-phenylamine
• CAS NO: 446-18-4
• Molecular Formula: C₇H₇FN₂O₂
• Molecular Weight: 170.14
• Mol File: 446-18-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: Benzenamine, 4-fluoro-2-methyl-5-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-fluoro-2-methyl-5-nitro-(446-18-4)
• EPA Substance Registry System: Benzenamine, 4-fluoro-2-methyl-5-nitro-(446-18-4)

Safety Data

• Hazardous Substances Data: 446-18-4(Hazardous Substances Data)

Usage

General Description

Benzenamine, 4-fluoro-2-methyl-5-nitro- is a chemical compound with the molecular formula C7H6FNO2. It is a derivative of aniline, consisting of a fluorine atom, a methyl group, and a nitro group attached to the benzene ring. Benzenamine, 4-fluoro-2-methyl-5-nitro- is used in the pharmaceutical industry for the synthesis of various drugs, including antipsychotic and antidepressant medications. It also has potential applications in organic synthesis and chemical research. Benzenamine, 4-fluoro-2-methyl-5-nitro- should be handled and used with caution due to its potential health and environmental hazards.

Upstream product

• 452-71-1 4-fluor-2-methylaniline 

Downstream Products

• 273401-26-6 N-(4-fluoro-2-methyl-5-nitrophenyl)acetamide 
• 1421372-47-5 N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-5-methylpyrimidine-2-amine 
• 173552-27-7 2-chloroethyl-N-[(4-fluoro-2-methyl-5-nitro)phenyl]-carbamate 
• 1011464-19-9 2-chloro-5-((4-fluoro-2-methyl-5-nitrophenylamino)methyl)-N-methylpyridin-4-amine 
• 1011464-05-3 5-((4-fluoro-2-methyl-5-nitrophenylamino)methyl)-N₄-isopropyl-N₂-methoxy-N₂-methylpyridine-2,4-diamine 
• 13429-10-2 N-(2-hydroxy-4-methylphenyl)acetamide 

Relevant articles and documents

EGFR INHIBITORS, COMPOSITIONS AND METHODS THERE OF

The present invention relates to compounds of Formula I, methods of using the compounds as EGFR inhibitors, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders s

HETEROARYL COMPOUNDS FOR KINASE INHIBITION

Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFRand mutant HER2 activity, are described herein.

KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES

The present invention relates to novel kinase inhibitors and modulator compounds useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferrably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.