13429-10-2

Basic information

• Product Name: 2'-HYDROXY-P-ACETOTOLUIDIDE, 98
• Synonyms: n-(2-hydroxy-4-methylphenyl)-acetamid;2'-HYDROXY-P-ACETOTOLUIDIDE, 98;N-(2-hydroxy-4-methylphenyl)acetamide;2'-Hydroxy-4'-methylacetoanilide;4'-Methyl-2'-hydroxyacetoanilide;Acetamide, N-(2-hydroxy-4-methylphenyl)-;N-(2-hydroxy-4-methylphenyl)acetamide(SALTDATA: FREE);2-Acetamido-5-methylphenol
• CAS NO: 13429-10-2
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.18914
• Mol File: 13429-10-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 170-172 °C(lit.)
• Appearance: /Solid
• CAS DataBase Reference: 2'-HYDROXY-P-ACETOTOLUIDIDE, 98(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-HYDROXY-P-ACETOTOLUIDIDE, 98(13429-10-2)
• EPA Substance Registry System: 2'-HYDROXY-P-ACETOTOLUIDIDE, 98(13429-10-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 13429-10-2(Hazardous Substances Data)

Usage

General Description

2'-Hydroxy-P-Acetotoluidide, 98, is a chemical compound usually available in high purity levels of 98 percent, often used for scientific research and development. Its molecular formula is C9H11NO2, indicating it is an organic compound made up of carbon, hydrogen, nitrogen, and oxygen. Given its specific formula and structure, it falls under the category of aromatic amines, which are often used in the manufacturing of dyes, pharmaceuticals, and polymers. Despite its prevalent use in various industries, handling and exposure to 2'-Hydroxy-P-Acetotoluidide must be carefully controlled due to potential health risks linked to many aromatic amines, such as skin and eye irritation, as well as potential long-term effects. Specific handling instructions and safety data should always be fully reviewed before it is used.

Upstream product

• 108-24-7 acetic anhydride 
• 2835-98-5 2-Hydroxy-4-methylanilin 
• 700-38-9 2-nitro-5-methylphenol 
• 74993-52-5 O-(3-methylphenyl)hydroxylamine 
• 937716-84-2 N-(3-methyl)phenoxyphthalimide 
• 1443440-55-8 N-(m-tolyloxy)acetamide 
• 103-89-9 4-Methylacetanilide 
• 106-49-0 p-toluidine 
• 29289-16-5 N-(2-iodo-4-methylphenyl)acetamide 
• 95-84-1 3-amino-4-hydroxytoluene 
• 631-57-2 Acetyl cyanide 
• 623-10-9 N-(4-methylphenyl)hydroxylamine 
• 446-18-4 4-fluoro-2-methyl-5-nitroaniline 

Downstream Products

• 73916-12-8 2-[(E)-2-(4-Chloro-phenyl)-vinyl]-6-methyl-benzooxazole 
• 73916-14-0 6-Methyl-2-[(E)-2-(4-nitro-phenyl)-vinyl]-benzooxazole 
• 73916-10-6 6-methyl-2-styrylbenzoxazole 
• 73916-11-7 2-[(E)-2-(4-Methoxy-phenyl)-vinyl]-6-methyl-benzooxazole 
• 73916-13-9 Dimethyl-{4-[(E)-2-(6-methyl-benzooxazol-2-yl)-vinyl]-phenyl}-amine 
• 384346-19-4 N-[4-methyl-2-(2-oxiranylmethoxy)phenyl]acetamide 
• 71472-58-7 3,4-dihydro-7-methyl-2H-1,4-benzoxazine 
• 105296-07-9 2-(Acetylamino)-4-<<2-methyl-4-(diethylamino)phenyl>imino>-5-methyl-2,5-cyclohexadien-1-one 
• 2584-04-5 4-[(E)-2-(6-Methyl-benzooxazol-2-yl)-vinyl]-benzoic acid methyl ester 

Relevant articles and documents

-

-

Cp?Rh(III)/Bicyclic Olefin Cocatalyzed C-H Bond Amidation by Intramolecular Amide Transfer

A bicyclic olefin was discovered as a cocatalyst in a Cp?Rh(III)-catalyzed C-H bond amidation proceeding by an intramolecular amide transfer in N-phenoxyacetamide derivatives. Combining experimental and theoretical studies, we propose that the olefin promotes a Rh(III) intermediate to undergo oxidative addition into the O-N bond to form a Rh(V) nitrenoid species and subsequently direct the nitrenoid to add to the ortho position. The amide directing group plays a dual role as a cleavable coordinating moiety as well as an essential coupling partner for the C-H amidation. This methodology was successfully applied to the late-stage diversification of natural products and a marketed drug under mild conditions.

Divergent reactivities of o-haloanilides with CuO nanoparticles in water: A green synthesis of benzoxazoles and o-hydroxyanilides

In the present study, three divergent reaction paths emerged when o-haloanilides were subjected to CuO nanoparticles in water. o-Halo (I, Br) phenylbenzamides in the presence of CuO nanoparticles and Cs2CO 3 in water at 100 °C provided o-hydroxyphenyl benzamides as the major product. However, a complete change in selectivity was observed in the presence of an organic base/ligand (TMEDA), giving 2-arylbenzoxazole as the exclusive product. The above selectivities were not clearly distinct when the corresponding alkylamides were treated either in the presence or absence of the ligand. A number of o-halophenyl alkylamides provided either exclusively o-dehalogenated products or a mixture of o-dehalogenated and o-hydroxylated products, but none gave 2-alkylbenzoxazoles. In addition to the above selectivities, the use of an environmentally friendly solvent (water) and base, and the recyclability of the catalyst make this procedure a benign alternative to the existing methods for the synthesis of these molecules, viz. o-hydroxybenzamides and o-arylbenzoxazoles.