4461-27-2

Upstream product

• 3315-16-0 silver cyanate 
• 103-80-0 phenylacetyl chloride 
• 17384-58-6 2-benzylidene-oxazolidine-4,5-dione 
• 79-37-8 oxalyl dichloride 
• 103-81-1 Benzeneacetamide 
• 1118-02-1 trimethylsilyl isocyanate 
• 95-50-1 1,2-dichloro-benzene 

Downstream Products

• 873988-67-1 1-Phenylacetyl-biuret 
• 78707-34-3 N-Phenylacetyl-N'-<3,4-dichlor-phenyl>-harnstoff 
• 89873-79-0 2,3-dimethyl-4,6,7-triphenyl-4H-pyrazolo<5,1-c><1,4>oxazine 
• 741716-56-3 t-butyl 2-methylene-3-phenyl-3-phenylacetylaminocarbonyloxypropanoate 
• 26172-73-6 dimethyl 2-benzylfuran-3,4-dicarboxylate 
• 69486-46-0 1-(N-phenylacetyl-carbamoyl)-2-cyanoaziridine 

Relevant academic research and scientific papers

Stereoselective iodocyclization of 3-acylamino-2-methylene alkanoates: Synthesis of analogues of N-benzoyl-syn-phenylisoserine

(Matrix Presented) A convenient approach to racemic analogues of N-benzoyl-syn-phenylisoserine was realized via the stereoselective iodocyclization of amides obtained from Baylis-Hillman adducts.

Carbamoyloxy derivatives of mutiline and their use as antibacterials

PCT No. PCT/EP96/05874 Sec. 371 Date Dec. 4, 1998 Sec. 102(e) Date Dec. 4, 1998 PCT Filed Dec. 19, 1996 PCT Pub. No. WO97/25309 PCT Pub. Date Jul. 17, 1997Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and derivatives thereof, in which R1 is ethyl or vinyl, Y is a carbamoyloxy group, in which the N-atom is unsubstituted, or mono- or di-substituted, are useful in the treatment of bacterial infections.

Acyl carbamate directing groups in nucleoside synthesis: Applications in the synthesis of 2′-deoxy-5-ethyl-4′-thiouridine

The use of the 3-O-(N-acyl)carbamoyl directing groups in the synthesis of the potent anti-Herpes virus agent 2′-deoxy-5-ethyl-4′-thio-D-uridine is described. This includes details of experiments to optimise the carbamate substitution and a multi-gram exemplification of the key steps.

Process for the preparation of acyl isocyanates

The invention concerns a process for the preparation of acyl isocyanates which consists of reacting oxalyl chloride with a salt selected from the group consisting of hydrohalides and sulphates of carboxamides and/or carbamates, unsubstituted on nitrogen, then heating the reaction mixture at a temperature between 30° and 150° C. The process is suitable for preparation of acyl isocyanates with excellent yields in easy to control operational conditions.