4461-38-5

Usage

Uses

Used in Pharmaceutical Industry:
4-Methanesulfonylbenzamide is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of non-steroidal anti-inflammatory drugs (NSAIDs), providing relief from inflammation and pain.
Used in Agrochemical Industry:
In the agrochemical sector, 4-methanesulfonylbenzamide is used as a building block in the production of pesticides, playing a crucial role in the development of compounds that protect crops from pests and diseases.
Used in Material Science:
4-Methanesulfonylbenzamide is utilized in the synthesis of dyes and rubber chemicals within the material science industry, contributing to the creation of a wide range of products with various applications, from textiles to industrial materials.

Upstream product

• 31218-79-8 1-ethyl-4-(methylsulfonyl)benzene 
• 850631-09-3 C₁₅H₁₅NO₃S 
• 104-96-1 4-methylsulfanylaniline 
• 4052-30-6 4-methylsulfonylbenzoic acid 
• 3185-99-7 Methyl p-tolyl sulfone 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 21382-98-9 p-cyanophenyl methyl sulfide 
• 98-10-2 benzenesulfonamide 
• 40913-92-6 4-methylsulfonylbenzoyl chloride 
• 22821-76-7 4-(methylsulfonyl)benzonitrile 

Relevant academic research and scientific papers

Direct Transformation of Ethylarenes into Primary Aromatic Amides with N -Bromosuccinimide and I2-Aqueous NH3

A variety of ethylarenes were converted into the corresponding primary aromatic amides in good yields via treatment with N-bromosuccinimide in the presence of a catalytic amount of 2,2′-azobis(isobutyronitrile) in a mixture of ethyl acetate and water, acetonitrile and water, or chloroform and water, followed by reaction with molecular iodine and aq NH3 in one pot. It was found that aryl α-bromomethyl ketones and/or aryl methyl ketones were formed at the first reaction step and their iodoform-type reaction occurred at the second reaction step to provide primary aromatic amides. The present reaction is a useful and practical transition-metal-free method for the preparation of primary aromatic amides from ethylarenes. (Chemical Equation Presented).

Microwave-assisted N-debenzylation of amides with triflic acid

A new and facile microwave-assisted protocol for the debenzylation of N-benzylamides with triflic acid has been developed. Both secondary and tertiary aliphatic or aromatic amides are obtained in moderate to good yields.

Chemoselective oxidations in water of functional groups

The organic functional groups, formyl, cyano, hydroxymethyl and methyl sulfenyl, are oxidized with high yields in water only by using TBHP and controlling the pH of the reaction medium. In the presence of (CTA)2SO4, the oxidation of the easily oxidizable sulfide group is prevented and a highly chemoselective process is obtained. The role of the surfactant is discussed.

FURTHER FUNCTIONAL GROUP OXIDATIONS USING SODIUM PERBORATE

Sodium perborate in acetic acid is an effective reagent for the oxidation of aromatic aldehydes to carboxylic acids, iodoarenes to (diacetoxyiodo)arenes, azines to N-oxides, and various types of sulfur heterocycles to S,S-dioxides.Nitriles are unaffected by the reagent in acetic acid, but undergo smooth hydration to amides when aqueous methanol is employed as solvent.