31218-79-8

Basic information

• Product Name: 4-ETHYLPHENYLMETHYLSULFONE
• Synonyms: 4-ETHYLPHENYLMETHYLSULFONE
• CAS NO: 31218-79-8
• Molecular Formula: C₉H₁₂O₂S
• Molecular Weight: 184.26
• Mol File: 31218-79-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 43-44 °C
• Boiling Point: 320.9±25.0 °C(Predicted)
• Appearance: /
• Density: 1.123±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-ETHYLPHENYLMETHYLSULFONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ETHYLPHENYLMETHYLSULFONE(31218-79-8)
• EPA Substance Registry System: 4-ETHYLPHENYLMETHYLSULFONE(31218-79-8)

Safety Data

• Hazardous Substances Data: 31218-79-8(Hazardous Substances Data)

Upstream product

• 110-05-4 di-tert-butyl peroxide 
• 100-41-4 ethylbenzene 
• 7143-01-3 Methanesulfonic anhydride 
• 25309-64-2 4-ethyl-1-iodobenzene 
• 67-68-5 dimethyl sulfoxide 
• 1585-07-5 1-bromo-4-ethylbenzene 
• 53120-15-3 1-Ethyl-4-methanesulfinyl-benzene 

Downstream Products

• 4461-38-5 4-(methylsulfonyl)benzamide 
• 10297-73-1 4-(methanesulfonyl)acetophenone 
• 50413-24-6 2-bromo-1-(4-methanesulfonylphenyl)ethanone 
• 383131-95-1 2-amino-4-(4′-methanesulfonylphenyl)thiazole 
• 1222-57-7 zolimidine 

Relevant articles and documents

One-pot NBS-promoted synthesis of imidazoles and thiazoles from ethylarenes in water

A facile and eco-friendly method has been developed for the synthesis of imidazoles and thiazoles from ethylarenes in water. The reaction proceeds via in situ formation of α-bromoketone using NBS as a bromine source as well as an oxidant, followed by trapping with suitable nucleophiles to provide the corresponding products in good yields under metal-free conditions.

Copper-catalyzed aerobic oxidation and cleavage/formation of C-S bond: A novel synthesis of aryl methyl sulfones from aryl halides and DMSO

With atmospheric oxygen as the oxidant, a novel copper(i)-catalyzed synthesis of aryl methyl sulfones from aryl halides and widely available DMSO is described. The procedure tolerates aryl halides with various functional groups (such as methoxy, acetyl, chloro, fluoro and nitro groups), which could afford aryl methyl sulfones in moderate to high yields. The copper-catalyzed aerobic oxidation and the cleavage/formation of C-S bond are the key steps for this transformation.

Mechanism of oxygenation of aryl methyl and diaryl sulphoxides by peroxomonophosphoric acid

The kinetics of oxygenation of the title sulphoxides by peroxomonophosphoric acid in aqueous acetic acid follows an overall second-order kinetics, first-order in each reactant. An analysis of the influence of [H+] reveals that H3PO5 is the active species in the oxidation. The structure - reactivity studies with different substituents on the phenyl ring give evidence for the formation of an electron deficient sulphonium ion intermediate as the correlation between log k2 and σ gives a negative ρ value (ρ=-0.47±0.09, r=0.988, s=0.03 at 35°C for aryl methyl sulphoxides and ρ=-0.54±0.11, r=0.983, s=0.07 at 35°C for diaryl sulphoxides). It is proposed that the mechanism involves the nucleophilic attack of the sulphoxide sulphur on the peroxo-oxygen of H3PO5 in the rate-limiting step.