4462-61-7

Basic information

• Product Name: 4-(Chlorocarbonyl)phenyl sulfone
• Synonyms: 4-(Chlorocarbonyl)phenyl sulfone
• CAS NO: 4462-61-7
• Molecular Formula: C₁₄H₈Cl₂O₄S
• Molecular Weight: 343.18192
• Mol File: 4462-61-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(Chlorocarbonyl)phenyl sulfone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Chlorocarbonyl)phenyl sulfone(4462-61-7)
• EPA Substance Registry System: 4-(Chlorocarbonyl)phenyl sulfone(4462-61-7)

Safety Data

• Hazardous Substances Data: 4462-61-7(Hazardous Substances Data)

Usage

General Description

4-(Chlorocarbonyl)phenyl sulfone, also known as p-toluenesulfonyl chloride, is a white solid chemical compound with the molecular formula C7H7ClO2S. It is used as a reagent in organic synthesis, particularly in the preparation of sulfonamides and sulfonylureas. 4-(Chlorocarbonyl)phenyl sulfone is highly reactive and can undergo various chemical reactions, including nucleophilic substitution and addition reactions. It is also a versatile building block in the pharmaceutical industry for the synthesis of various drug molecules. Additionally, 4-(Chlorocarbonyl)phenyl sulfone is utilized as a chlorinating agent and as a precursor for the preparation of dyes and pigments. However, it is important to handle this compound with caution as it is corrosive and can cause skin and eye irritation upon contact.

Upstream product

• 3965-53-5 4,4'-dicarbomethoxydiphenyl sulfone 
• 104629-59-6 4-(4-Chlorocarbonyl-benzenesulfonyl)-benzoic acid 
• 2449-35-6 bis(4-carboxyphenyl)sulfone 

Downstream Products

• 1242188-85-7 N,N'-[4,4'-sulfonylbis(benzoyl)]-bis{4,4'-(p-fluorobenzyl)-1,2-dihydroisoquinaldonitrile} 
• 1242188-88-0 p-{1-[4-(p-fluorobenzyl)isoquinolyl]carbonyl}diphenyl sulfone 
• 80-08-0 dapsone 
• 3112-80-9 bis(p-anisyl)sulfone 
• 80-09-1 4,4'-sulfonediphenol 
• 66-38-6 4,4'-sulfonylbisbenzaldehyde 
• 111797-42-3 4,4'-sulfonyl-di-benzoic acid bis-(2-methoxy-ethyl ester) 

Relevant articles and documents

Synthesis and characterization of aromatic poly(amides) based on 3,5-diamino-N-cyclopropylbenzamide

Three aromatic poly(amides) (PAs) were prepared, one of them containing a dimethyldiphenylsilane unit from a new aromatic diamine monomer with a bulky pendant polar group. All PAs were obtained in high yield and the inherent viscosities were in the range

KINETICS AND MECHANISM OF THE REACTION OF CARBOXYLIC ACIDS WITH THIONYL CHLORIDE IN THE PRESENCE OF DIMETHYLFORMAMIDE

A study was carried out on the reaction of carboxylic acids with thionyl chloride in the presence of dimethylformamide.Correlation analysis of a reaction series of substituted benzoic acids with thionyl chloride indicated that this reaction is electrophilic in nature.The ionic complex of dimethylformamide and thionyl chloride reacts rapidly with the carboxylic acid to release hydrogen chloride and form the chloride of the mixed anhydride of thiodimethyliminium and the carboxylic acid, which undergoes rearrangement in the rate-limiting step to regenerate the catalyst and liberate the acid chloride and sulfur dioxide.