4465-44-5

Basic information

• Product Name: N-Trityl-L-serine methyl ester
• Synonyms: (S)-methyl 3-hydroxy-2-(tritylamino)propanoate;N-(TriphenylMethyl)-L-serine Methyl Ester;N-Trityl-L-serine Methyl Ester Trt-Ser-OMe;(4S)-4-aMinooxolan-3-one;(diphenylMethyl)benzene;Trt-Ser-OMe;N-Trityl-L-serine methyl ester 99%;Trt-L-Ser-Ome
• CAS NO: 4465-44-5
• Molecular Formula: C₂₃H₂₃NO₃
• Molecular Weight: 361.43
• Product Categories: pharmacetical;Amino Acid Derivatives;Peptide Synthesis;Serine
• Mol File: 4465-44-5.mol
• Article Data: 41

Chemical Properties

• Melting Point: 148-150 °C(lit.)
• Boiling Point: 538.2 °C at 760 mmHg
• Flash Point: 279.3 °C
• Appearance: /
• Density: 1.169 g/cm³
• Vapor Pressure: 2.04E-12mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• PKA: 14.01±0.10(Predicted)
• CAS DataBase Reference: N-Trityl-L-serine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-Trityl-L-serine methyl ester(4465-44-5)
• EPA Substance Registry System: N-Trityl-L-serine methyl ester(4465-44-5)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 4465-44-5(Hazardous Substances Data)

Usage

General Description

N-Trityl-L-serine methyl ester is a chemical compound consisting of a trityl-protected L-serine molecule with a methyl ester group attached. It is commonly used in peptide synthesis and as a building block for various organic compounds. The trityl group serves as a protective group for the serine amino acid, preventing unwanted reactions during the synthesis process. The methyl ester group allows for easy manipulation and modification of the compound, making it a versatile tool for chemical synthesis. Overall, N-Trityl-L-serine methyl ester is an important intermediate in organic chemistry, particularly in the production of peptides and other biologically active molecules.

InChI:InChI=1/C23H23NO3/c1-27-22(26)21(17-25)24-23(18-11-5-2-6-12-18,19-13-7-3-8-14-19)20-15-9-4-10-16-20/h2-16,21,24-25H,17H2,1H3/t21-/m0/s1

Upstream product

• 5680-80-8 methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride 
• 76-83-5 trityl chloride 
• 141-78-6 ethyl acetate 
• 2788-84-3 (S)-serine methyl ester 

Downstream Products

• 257887-94-8 1-O-(5'-carbomethoxypentyl)-2-tetrahydropyranyl-sn-glyceryl 2,2,2-trichloro-tert-butyl 2-carbomethoxy-2-(N-triphenylmethylamino)ethyl phosphite 
• 181637-40-1 (2R)-N-triphenylmethyl-3-iodoalanine methyl ester 
• 441347-98-4 methyl O-(3-bromophenyl)-N-triphenylmethyl-L-serinate 
• 918149-10-7 C₂₄H₂₁NO₄ 
• 1221399-79-6 3-(3,5-difluoro-phenoxy)-2-(tritylamino)-propionic acid methyl ester 
• 75154-68-6 methyl (2S)-N-tritylaziridine-2-carboxylate 
• 161009-62-7 (S)-3-[2-(2-Methoxy-ethoxymethoxy)-5-nitro-benzyloxy]-2-(trityl-amino)-propionic acid methyl ester 
• 161009-63-8 (S)-3-[5-(2-Methoxy-ethoxymethoxy)-2-nitro-benzyloxy]-2-(trityl-amino)-propionic acid methyl ester 
• 76357-12-5 (S)-methyl3-((methylsulfonyl)oxy)-2-(tritylamino)propanoate 
• 119147-46-5 O-<4,6-Bis(octadecyloxy)-1,3,5-triazin-2-yl>-N-trityl-L-serin-methylester 
• 151074-52-1 (S)-3-(toluene-4-sulfonyloxy)-2-tritylaminopropionic acid methyl ester 
• 4465-45-6 (S)-3-hydroxy-2-(tritylamino)propanoic acid 

Relevant articles and documents

Preparation method of 2,3-diamido methyl propionate

The invention provides a preparation method of 2,3-diamido methyl propionate. According to the method, serine is used as a raw material, in methyl alcohol, thionyl chloride is used as a catalyst for preparing serine methylester, then the serine methyleste

Highly Chemoselective Deprotection of the 2,2,2-Trichloroethoxycarbonyl (Troc) Protecting Group

Nonreducing, pH-neutral conditions for the selective cleavage of the 2,2,2-trichloroethoxycarbonyl (Troc) protecting group are reported. Using trimethyltin hydroxide in 1,2-dichloroethane, Troc-protected alcohols, thiols, and amines can be selectively unmasked in the presence of various functionalities that are incompatible with the reducing conditions traditionally used to remove the Troc group. This mild deprotection protocol tolerates a variety of other hydrolytically sensitive and acid/base-sensitive moieties as well.

PHOSPHONATE COMPOUNDS FOR TREATMENT OF IMMUNE AND INFLAMMATORY DISORDERS

Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I" and I''' or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit