446830-54-2Relevant academic research and scientific papers
Long-wavelength absorbing fluorescent polymethine dyes derived from the 6-(N,N-diethylamino)-1,2,3,4-tetrahydroxanthylium system
Concei??o,Ferreira,Prostota,Kachkovsky,Ferreira, L.F.Vieira,Santos
, p. 218 - 226 (2017)
Several new dyes derivatives of the “rhodamine-like” 6-(N,N-diethylamino)-1,2,3,4-tetrahydroxanthylium heterocyclic system displaying absorption within the near-infrared were synthesized. The photochemical behaviour of these molecules was evaluated in dic
Synthesis of (Z)-3-(arylamino)-1-(3-phenylimidazo[1,5-a]pyridin-1-yl)prop-2-en-1-ones as potential cytotoxic agents
Anchi, Pratibha,Donthiboina, Kavitha,Godugu, Chandraiah,Kamal, Ahmed,Mani, Geeta Sai,Shankaraiah, Nagula,Sunkari, Satish
, (2020/07/31)
The new derivatives based on (Z)-3-(arylamino)-1-(3-phenylimidazo[1,5-a]pyridin-1-yl)prop-2-en-1-one scaffold was synthesized and evaluated for their in vitro cytotoxic potential against a panel of cancer cell lines, viz., A549 (human lung cancer), HCT-116 (human colorectal cancer), B16F10 (murine melanoma cancer), BT-474 (human breast cancer), and MDA-MB-231 (human triple-negative breast cancer). Among them, many of the synthesized compounds exhibited promising cytotoxic potential against the panel of tested cancer cell lines with IC50 50 value of 1.21 ± 0.14 μM. Flow cytometric analysis revealed that compound 15i arrested the G0/G1 phase of the cell cycle. Moreover, increased reactive oxygen species (ROS) generation, clonogenic assay, acridine orange staining, DAPI nuclear staining, measurement of mitochondrial membrane potential (ΔΨm), and annexin V-FITC assays revealed that compound 15i promoted cell death through apoptosis.
Synthesis and biological evaluation of new bisindole-imidazopyridine hybrids as apoptosis inducers
Sunkari, Satish,Bonam, Srinivasa Reddy,Rao, A.V. Subba,Riyaz, Sd,Lakshma Nayak,Kumar, Halmuthur Mahabalarao Sampath,Kamal, Ahmed,Nagendra Babu, Bathini
, p. 484 - 494 (2019/03/29)
A series of diindolylmethanes (5a-t) were designed, synthesized, and examined for their cytotoxicity against four human cancer cell lines like prostate (DU-145), lung (A549), breast (MCF-7) and cervical cancer (HeLa). These results revealed that among all
Syntheses and optical properties of BODIPY derivatives based on imidazo[1,5-a]pyridine
Hu, Jinfa,Li, Yu,Wu, Yuxiao,Liu, Wei,Wang, Yong,Li, Yahong
, p. 645 - 647 (2015/05/27)
A series of covalently linked dyads 3a-3e incorporating imidazo[1,5-a]pyridine derivatives with boron dipyrromethene (BODIPY) fragment have been synthesized by a concise procedure. The absorptions with high molar extinction coefficient for 3a-3e have been
Synthesis and biological evaluation of imidazo[1,5-a]pyridine-benzimidazole hybrids as inhibitors of both tubulin polymerization and PI3K/Akt pathway
Kamal, Ahmed,Subba Rao,Lakshma Nayak,Subba Reddy,Swapna, Konderu,Ramakrishna,Alvala, Mallika
, p. 9864 - 9880 (2015/01/08)
A series of imidazo[1,5-a]pyridine-benzimidazole hybrids (5a-aa) were prepared and evaluated for their cytotoxic activity against a panel of sixty human tumor cell lines. Among them compounds 5d and 5l showed significant cytotoxic activity with GI50
Synthesis and anticancer activity of oxindole derived imidazo[1,5-a] pyrazines
Kamal, Ahmed,Ramakrishna,Raju,Rao, A.V. Subba,Viswanath,Nayak, V. Lakshma,Ramakrishna, Sistla
, p. 2427 - 2435 (2011/06/24)
A series of oxindole derivatives of imidazo[1,5-a]pyrazines were prepared and confirmed by 1H NMR, mass and HRMS data. These compounds were evaluated for their anticancer activity against a panel of 52 human tumor cell lines derived from nine d
