446840-29-5

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 111051-16-2 [(1S,4R)-4-(hydroxymethyl)-2-cyclobutenyl]methyl acetate 

Downstream Products

• 446840-30-8 (-)-[(1S,4R)-4-({[tert-butyl(diphenyl)silyl]oxy}methyl)cyclobut-2-enyl]methanol 
• 446840-31-9 3-benzoyl-1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-cyclobut-2-enylmethyl]-5-methyl-1H-pyrimidine-2,4-dione 
• 446840-34-2 (+)-9-[(1S,4R)-4-({[tert-butyl(diphenyl)silyl]oxy}methyl)cyclobut-2-enyl]methyl-9H-purin-6-ylamine 
• 446840-32-0 1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-cyclobut-2-enylmethyl]-5-methyl-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

A short route to new cyclobutene nucleoside analogues

Nucleoside analogues (+)-4a and (+)-4b were obtained in non-racemic form by a short and efficient way. The key step was a Mitsunobu reaction of alcohol (-)-8 with adenine or protected thymine. The title products were obtained after deprotection steps.

Synthesis of Novel Triazolo Cyclobutane Nucleoside Analogs

Synthesis of triazolo-cyclobutane nucleosides analogs is reported. These molecules have been obtained by a short and efficient sequence involving a click azide-alkyne cycloaddition following by cis-hydroxylation in the key step.