446840-32-0

Upstream product

• 446840-29-5 (-)-[(1S,4R)-4-({[tert-butyl(diphenyl)silyl]oxy}methyl)cyclobut-2-enyl]methyl acetate 
• 446840-30-8 (-)-[(1S,4R)-4-({[tert-butyl(diphenyl)silyl]oxy}methyl)cyclobut-2-enyl]methanol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 4330-20-5 N-3-benzoylthymine 
• 446840-31-9 3-benzoyl-1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-cyclobut-2-enylmethyl]-5-methyl-1H-pyrimidine-2,4-dione 

Downstream Products

• 863485-93-2 (+)-N₁-[(1S,2R,3S)-2-(tert-butyl-diphenyl-silyloxymethyl)-3-hydroxy-cyclobutyl]methyl-5-methyl-1H,3H-pyrimidine-2,4-dione 
• 863485-94-3 (-)-N₁-[(1S,2R,4R)-2-(tert-butyl-diphenyl-silyloxymethyl)-4-hydroxy-cyclobutyl]methyl-5-methyl-1H,3H-pyrimidine-2,4-dione 
• 863485-99-8 (-)-N₁-[(1S,2S,3R,4R)-2,3-dihydroxy-4-(tert-butyl-diphenyl-silyloxymethyl)-cyclobutyl]methyl-5-methyl-1H,3H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Synthesis of mono- and polyhydroxylated cyclobutane nucleoside analogs

Enantiomerically enriched cyclobutene compounds 13 and 24 are good precursors of several cyclobutane nucleoside analogs. The synthetic ways involve, in the key step, either hydroboration or dihydroxylation.

A short route to new cyclobutene nucleoside analogues

Nucleoside analogues (+)-4a and (+)-4b were obtained in non-racemic form by a short and efficient way. The key step was a Mitsunobu reaction of alcohol (-)-8 with adenine or protected thymine. The title products were obtained after deprotection steps.