446883-84-7

Basic information

• Product Name: BENZENESULFONYL CHLORIDE, 4-[4-[4-(TRIFLUOROMETHYL)PHENYL]-2-THIAZOLYL]-
• Synonyms: 4-[4-(4-TRIFLUOROMETHYL-PHENYL)-THIAZOL-2-YL]-BENZENESULFONYL CHLORIDE;BENZENESULFONYL CHLORIDE, 4-[4-[4-(TRIFLUOROMETHYL)PHENYL]-2-THIAZOLYL]-;4-[4-[4-(Trifluoromethyl)phenyl]-2-thiazolyl]-benzenesulfonylchloride;4-(4-(4-(trifluoroMethyl)phenyl)thiazol-2-yl)
• CAS NO: 446883-84-7
• Molecular Formula: C₁₆H₉ClF₃NO₂S₂
• Molecular Weight: 403.831
• Mol File: 446883-84-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 496.9 °C at 760 mmHg
• Flash Point: 254.3 °C
• Appearance: /
• Density: 1.48 g/cm³
• Vapor Pressure: 1.59E-09mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: BENZENESULFONYL CHLORIDE, 4-[4-[4-(TRIFLUOROMETHYL)PHENYL]-2-THIAZOLYL]-(CAS DataBase Reference)
• NIST Chemistry Reference: BENZENESULFONYL CHLORIDE, 4-[4-[4-(TRIFLUOROMETHYL)PHENYL]-2-THIAZOLYL]-(446883-84-7)
• EPA Substance Registry System: BENZENESULFONYL CHLORIDE, 4-[4-[4-(TRIFLUOROMETHYL)PHENYL]-2-THIAZOLYL]-(446883-84-7)

Safety Data

• Hazardous Substances Data: 446883-84-7(Hazardous Substances Data)

Usage

General Description

Benzenesulfonyl chloride, 4-[4-[4-(trifluoromethyl)phenyl]-2-thiazolyl]-, also known as 4-[(4-(trifluoromethyl)phenyl)thiazol-2-yl]benzenesulfonyl chloride, is a chemical compound with the molecular formula C17H10ClF3NO2S2. It is commonly used as a reagent in organic synthesis, particularly in the preparation of pharmaceuticals and agrochemicals. Benzenesulfonyl chloride, 4-[4-[4-(trifluoromethyl)phenyl]-2-thiazolyl]- is known for its ability to form covalent bonds with various functional groups, making it a valuable tool in the development of new chemical entities. It is important to handle this compound with caution, as it is toxic and can cause irritation to the skin and eyes.

InChI:InChI=1/C16H9ClF3NO2S2/c17-25(22,23)13-7-3-11(4-8-13)15-21-14(9-24-15)10-1-5-12(6-2-10)16(18,19)20/h1-9H

Upstream product

• 533867-33-3 2-(4-bromo-phenyl)-4-(4-trifluoromethyl-phenyl)-5-trimethylsilylthiazole 
• 533867-29-7 2-(4-bromo-phenyl)-4-(4-trifluoromethyl-phenyl)thiazole 
• 533867-27-5 4-(4-trifluoromethyl-phenyl)-2-phenyl-thiazole 
• 26197-93-3 p-bromothiobanzamide 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 383-53-9 2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone 
• 623-00-7 4-bromobenzenecarbonitrile 
• 873-74-5 4-Aminobenzonitrile 
• 4714-67-4 4-aminobenzothioamide 

Downstream Products

• 1190615-51-0 tert-butyl (2R,5S)-2-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(pyridin-3-yl)methyl]-5-(4-{[(4-{4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}phenyl)sulfonyl]amino}benzyl)pyrrolidine-1-carboxylate trifluoroacetate 
• 1190393-26-0 tert-butyl(2R,5S)-2-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl-5-(4-{[(4-{4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}phenyl)sulfonyl]amino}benzyl)pyrrolidine]-1-carboxylate 
• 533867-50-4 (R)-N-(2-hydroxy-2-pyridin-3-yl-ethyl)-2-(4-{4-[4-trifluoromethyl-phenyl-thiazol-2-yl]-benzenesulfonylamino}-phenyl)-acetamide 

Relevant articles and documents

HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS

The present invention provides compounds of Formula I, pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.