533867-27-5

Basic information

• Product Name: Thiazole, 2-phenyl-4-[4-(trifluoromethyl)phenyl]-
• Synonyms: Thiazole, 2-phenyl-4-[4-(trifluoromethyl)phenyl]-;2-phenyl-4-[4-(trifluoroMethyl)phenyl]-1,3-thiazole;2-Phenyl-4-(4-(trifluoromethyl)phenyl)thiazole
• CAS NO: 533867-27-5
• Molecular Formula: C₁₆H₁₀F₃NS
• Molecular Weight: 305.3175096
• EINECS: -0
• Mol File: 533867-27-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Thiazole, 2-phenyl-4-[4-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazole, 2-phenyl-4-[4-(trifluoromethyl)phenyl]-(533867-27-5)
• EPA Substance Registry System: Thiazole, 2-phenyl-4-[4-(trifluoromethyl)phenyl]-(533867-27-5)

Safety Data

• Hazardous Substances Data: 533867-27-5(Hazardous Substances Data)

Upstream product

• 383-53-9 2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone 
• 2227-79-4 benzenecarbothioamide 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 28170-13-0 thiobenzoic acid potassium salt 

Downstream Products

• 533867-50-4 (R)-N-(2-hydroxy-2-pyridin-3-yl-ethyl)-2-(4-{4-[4-trifluoromethyl-phenyl-thiazol-2-yl]-benzenesulfonylamino}-phenyl)-acetamide 
• 446883-84-7 4-[4-(4-trifluoromethyl-phenyl)-thiazol-2-yl]-bezenesulfonyl chloride 

Relevant articles and documents

Preparation method of 2, 4-disubstituted thiazole compound

The invention discloses a preparation method of a 2, 4-disubstituted thiazole compound. The method comprises the following steps: carrying out heating reflux reaction on substituted carboxylic acid inthionyl chloride to obtain yellow transparent liquid, and adding dichloromethane to dilute for later use; in an ice bath, slowly dropwise adding the substituted acyl chloride solution into ammonia water while stirring, stirring at room temperature to separate out a white solid, and after the reaction is finished, carrying out suction filtration, washing and drying to obtain substituted amide; carrying out reflux on substituted amide and Lawesson in tetrahydrofuran, carrying out rotary evaporation to remove the solvent after the reaction is finished, and carrying out column purification on thecrude product to obtain substituted sulfamide. The preparation method comprises the following steps: putting substituted sulfamide, ethanol, triethylamine and an alpha-bromocarbonyl compound into a pressure reaction tank, putting the pressure reaction tank into an annular focusing single-mode microwave synthesizer for irradiation, and cooling with compressed air to obtain a target compound. Basedon microwave synthesis, the invention has the advantages of short reaction time, high yield, high heating speed, environment friendliness and the like, and provides a microwave synthesis method of a2, 4-disubstituted thiazole compound.

Exploration and Optimization of an Efficient One-pot Sequential Synthesis of Di/tri-substituted Thiazoles from α-Bromoketones, Thioacids Salt, and Ammonium Acetate

Exploration of scope of an optimized one-pot sequential procedure for preparing of 2,4-di- and 2,4,5-tri-substituted thiazoles has been accomplished. The synthesis was performed by the initial formation of a β-keto-thioester intermediate from nucleophilic substitution of α-bromoketones with thioacid potassium salts, followed by treatment with ammonium acetate and one equivalent of acetic acid in toluene to form imine intermediate eventually leading to cyclization yielding thiazoles. This procedure should be highlighted with a flexible way to control the substitution pattern around thiazole ring by choosing appropriately substituted α-bromoketones even containing acid labile functionality and thioacid potassium salts, and thus its applicability is very wide.