4469-65-2

Upstream product

• 4469-64-1 2-(2-phenyl-allyl)-malonic acid diethyl ester 
• 85291-68-5 (1,3-dibromopropan-2-yl)benzene 
• 4469-66-3 4-Phenyl-2-methoxycarbonyl-4-enoic acid methyl ester 

Downstream Products

• 16433-43-5 4-phenyl-1-pentanoic acid 
• 4300-13-4 dimethyl 2-(2-phenylpropyl)malonate 
• 5747-06-8 4-phenylpent-4-enoic acid 
• 4469-66-3 4-Phenyl-2-methoxycarbonyl-4-enoic acid methyl ester 

Relevant academic research and scientific papers

CYSTEINE PROTEASE INHIBITORS

The present invention is directed to compounds that are inhibitors of cysteine protease, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceut

Research on cyclobutane compounds of biological interest. III. Syntheses and structure activity (antiinflammatory and antalgic) relationships of 3-substituted cyclobutane carboxylic acids

Antiinflammatory and analgesic activities of 3 substituted cyclobutanecarboxylic acids are pointed out and their structure-activity relationship examined according to the Hansch method. This analysis shows the influence of the steric and lipophilic parameters and this quantitative basis let us realize the synthesis of two acids, the analgesic acitivities of which are very much improved. Attempted quantitative correlations between physiochemical parameters and antiinflammatory activity were unsuccessful. This is imputable to a too imprecise representation of the steric effect which plays a primordial part in this kind of activity.