4469-78-7

Basic information

• Product Name: 2-PROPOXYANILINE HYDROCHLORIDE
• Synonyms: 2-propoxybenzenamine
• CAS NO: 4469-78-7
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.21
• Mol File: 4469-78-7.mol

Chemical Properties

• Boiling Point: 249.3°Cat760mmHg
• Flash Point: 106.6°C
• Appearance: /
• Density: 1.016g/cm³
• Vapor Pressure: 0.0231mmHg at 25°C
• Refractive Index: 1.536
• CAS DataBase Reference: 2-PROPOXYANILINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PROPOXYANILINE HYDROCHLORIDE(4469-78-7)
• EPA Substance Registry System: 2-PROPOXYANILINE HYDROCHLORIDE(4469-78-7)

Safety Data

• Hazardous Substances Data: 4469-78-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Propoxyaniline hydrochloride is used as a key intermediate in the synthesis of various pharmaceuticals. Its ability to serve as a building block for more complex chemical structures makes it essential in the development of new drugs and medications.
Used in Dye Industry:
In the dye industry, 2-Propoxyaniline hydrochloride is utilized as a precursor for the production of various dyes. Its chemical properties allow for the creation of a wide range of colors and hues, contributing to the diversity of dyes available in the market.
Used in Research and Industrial Processes:
2-Propoxyaniline hydrochloride is commonly used in research and industrial processes due to its versatility and reactivity. Its role as an intermediate in the synthesis of organic compounds makes it a valuable component in the development of new chemical products and technologies.
Used for Anesthetic and Analgesic Properties:
Owing to its mild anesthetic and analgesic properties, 2-Propoxyaniline hydrochloride finds applications in the formulation of medications aimed at providing pain relief and local anesthesia. Its effectiveness in these areas makes it a valuable asset in the pharmaceutical sector.

InChI:InChI=1/C9H13NO/c1-2-7-11-9-6-4-3-5-8(9)10/h3-6H,2,7,10H2,1H3

Upstream product

• 88-75-5 2-hydroxynitrobenzene 
• 241147-96-6 2-(4-(tert-butyl)phenyl)benzo[d][1,3,2]dioxaborole 
• 27096-64-6 2-(allyloxy)aniline 
• 106-94-5 propyl bromide 
• 95-55-6 2-amino-phenol 
• 86255-27-8 silver(I) 2-nitrophenoxide 
• 65347-84-4 (2-Propoxy-phenyl)-carbamic acid 2-morpholin-4-yl-ethyl ester 
• 3079-53-6 1-nitro-2-propoxybenzene 

Downstream Products

• 101602-54-4 N-[2-(6-methyl-[2]pyridyl)-ethyl]-2-propoxy-aniline 
• 98771-56-3 ethyl 1,6-dihydro-2-(2-propoxyanilino)-6-oxo-5-pyrimidinecarboxylate 
• 553-79-7 2-amino-4-nitro-1-propoxybenzene 
• 114559-72-7 1-((1R,3R,5S)-8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(2-propoxy-phenyl)-urea 
• 374909-84-9 (4,4,7,8-tetramethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene)(2-propoxyphenyl)amine 
• 98772-02-2 1,6-dihydro-2-(2-propoxyanilino)-6-oxo-5-pyrimidinecarboxylic acid 
• 106589-00-8 2-amino>isophthalic acid 
• 32223-62-4 2-propoxyphenyl isocyanate 
• 857825-61-7 1-iodo-2-propoxybenzene 
• 55792-51-3 acetic acid-(2-propoxy-anilide) 
• 109090-42-8 2-propoxy-N-(2-[4]pyridyl-ethyl)-aniline 

Relevant articles and documents

Investigation of hydro-lipophilic properties of n-alkoxyphenylhydroxynaphthalenecarboxamides ?

The evaluation of the lipophilic characteristics of biologically active agents is indispensable for the rational design of ADMET-tailored structure–activity models. N-Alkoxy-3-hydroxynaphthalene-2-carboxanilides, N-alkoxy-1-hydroxynaphthalene-2-carboxanilides, and N-alkoxy-2-hydroxynaphthalene-1-carboxanilides were recently reported as a series of compounds with antimycobacterial, antibacterial, and herbicidal activity. As it was found that the lipophilicity of these biologically active agents determines their activity, the hydro-lipophilic properties of all three series were investigated in this study. All 57 anilides were analyzed using the reversed-phase high-performance liquid chromatography method for the measurement of lipophilicity. The procedure was performed under isocratic conditions with methanol as an organic modifier in the mobile phase using an end-capped non-polar C18 stationary reversed-phase column. In the present study, a range of software lipophilicity predictors for the estimation of clogP values of a set of N-alkoxyphenylhydroxynaphthalenecarboxamides was employed and subsequently cross-compared with experimental parameters. Thus, the empirical values of lipophilicity (logk) and the distributive parameters (π) were compared with the corresponding in silico characteristics that were calculated using alternative methods for deducing the lipophilic features. To scrutinize (dis)similarities between the derivatives, a PCA procedure was applied to visualize the major differences in the performance of molecules with respect to their lipophilic profile, molecular weight, and violations of Lipinski’s Rule of Five.

Enhanced Reactivity of Aerobic Diimide Olefin Hydrogenation with Arylboronic Compounds: An Efficient One-Pot Reduction/Oxidation Protocol

A catalyst-free and efficient method for simultaneous olefin hydrogenation and oxidation of arylboronate esters to phenols with hydrazine hydrate and molecular oxygen is presented. The process is based on the utilization of a readily available Lewis acidic arylboron compound, which evades common problems associated with the catalyst-free aerobic hydrogenation of olefins with diimide. Using an operationally simple procedure, the protocol smoothly delivers phenol derivatives and various alkanes in excellent yields with remarkable functional group compatibility. The method allows the reaction to be scaled up to 1 g of the starting materials.

Synthesis and Biological Evaluation of N-Alkoxyphenyl-3-hydroxynaphthalene-2-carboxanilides

A series of fifteen new N-alkoxyphenylanilides of 3-hydroxynaphthalene-2-carboxylic acid was prepared and characterized. Primary in vitro screening of the synthesized compounds was performed against Staphylococcus aureus, three methicillin-resistant S. aureus strains, Mycobacterium tuberculosis H37Ra and M. avium subsp. paratuberculosis. Some of the tested compounds showed antibacterial and antimycobacterial activity against the tested strains comparable with or higher than that of the standards ampicillin or rifampicin. 3-Hydroxy-N-(2-propoxyphenyl)naphthalene-2-carboxamide and N-[2-(but-2-yloxy)-phenyl]-3-hydroxynaphthalene-2-carboxamide had MIC = 12 μM against all methicillin-resistant S. aureus strains; thus their activity is 4-fold higher than that of ampicillin. The second mentioned compound as well as 3-hydroxy-N-[3-(prop-2-yloxy)phenyl]-naphthalene-2-carboxamide had MICs = 23 μM and 24 μM against M. tuberculosis respectively. N-[2-(But-2-yloxy)phenyl]-3-hydroxynaphthalene-2-carboxamide demonstrated higher activity against M. avium subsp. paratuberculosis than rifampicin. Screening of the cytotoxicity of the most effective antimycobacterial compounds was performed using THP-1 cells, and no significant lethal effect was observed for the most potent compounds. The compounds were additionally tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. N-(3-Ethoxyphenyl)-3-hydroxynaphthalene-2-carboxamide (IC50 = 4.5 μM) was the most active PET inhibitor. The structure-activity relationships are discussed.

COUMARIN DERIVATIVES AND METHODS OF USE IN TREATING CYSTIC FIBROSIS, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, AND MISFOLDED PROTEIN DISORDERS

Novel CFTR corrector compounds that are effective in rescuing halide efflux, delF508-CFTR protein processing, and apical functional chloride ion transport in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cyst

COUMARIN DERIVATIVES AND METHODS OF USE IN TREATING HYPERPROLIFERATIVE DISEASES

Coumarin derivative compounds and methods for the treatment of hyperproliferative diseases, such as cancer, polycystic kidney disease, and fibrosis of different tissues (e.g., idiopathic pulmonary fibrosis), are provided. The methods include administering

An insight into the extraction of transition metal ions by picolinamides associated with intramolecular hydrogen bonding and rotational isomerization

The clear connection between molecular structures of N-substituted picolinamides and extraction behaviour has been rationalized by highlighting the relationship between intramolecular hydrogen bonding and rotational isomerism. To this aim aromatic pyridine-2,6-dicarboxamides 1a-1c with N-substitution and their analogues 3a and 3b containing intramolecular hydrogen bonds were designed and synthesized. The results from the liquid-liquid extraction towards some representative transition metal picrates including Ag+, Hg 2+, Pb2+, Cd2+, Zn2+, Cu 2+, Co2+ and Ni2+ salts demonstrated that the higher selectivity and efficiency towards Hg2+ (88.6-95.4%) over other metal cations stem mainly from N-substitution via disruption of intramolecular H-bonding. X-ray structural analysis, and ordinary and variable-temperature proton and carbon NMR experiments provided supporting information for expounding the difference in extraction ability among these ligands, particularly the importance of N-substitution that leads to the formation of rotamers affecting the extraction process.

THIENOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS

The present invention relates to novel pharmaceutical compositions of general formula (I) comprising thienopyrimidine compounds. Moreover, the present invention relates to the use of the thienopyrimidine compounds of the invention for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.

Synthesis and characterization of some polyalkyl- and polyalkoxy-anilines

Since poly-3-alkylthiophenes are more processible than polythiophene, it is expected that poly-o-alkyl and poly-o-alkoxyanilines will evince better processibility than polyaniline.Hence, poly-o-alkyl and poly-o-alkoxyanilines (alkyl=CH3, C2H5, C3H7, alkox