4469-78-7

Basic information

• Product Name: 2-PROPOXYANILINE HYDROCHLORIDE
• Synonyms: 2-propoxybenzenamine
• CAS NO: 4469-78-7
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.21
• Mol File: 4469-78-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 249.3°Cat760mmHg
• Flash Point: 106.6°C
• Appearance: /
• Density: 1.016g/cm³
• Vapor Pressure: 0.0231mmHg at 25°C
• Refractive Index: 1.536
• CAS DataBase Reference: 2-PROPOXYANILINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PROPOXYANILINE HYDROCHLORIDE(4469-78-7)
• EPA Substance Registry System: 2-PROPOXYANILINE HYDROCHLORIDE(4469-78-7)

Safety Data

• Hazardous Substances Data: 4469-78-7(Hazardous Substances Data)

Usage

General Description

2-Propoxyaniline hydrochloride is a chemical compound with the formula C9H13ClN2O. It is an organic salt that is used in the manufacturing of pharmaceuticals and dyes. It is a white to pale yellow crystalline powder that is soluble in water and organic solvents. 2-PROPOXYANILINE HYDROCHLORIDE is typically used as an intermediate in the synthesis of various organic compounds, including pharmaceuticals and agrochemicals. It serves as a building block for the creation of more complex chemical structures and is commonly utilized in research and industrial processes. Additionally, 2-Propoxyaniline hydrochloride is known for its mild anesthetic and analgesic properties, making it a versatile and valuable chemical in various applications.

InChI:InChI=1/C9H13NO/c1-2-7-11-9-6-4-3-5-8(9)10/h3-6H,2,7,10H2,1H3

Upstream product

• 106-94-5 propyl bromide 
• 95-55-6 2-amino-phenol 
• 241147-96-6 2-(4-(tert-butyl)phenyl)benzo[d][1,3,2]dioxaborole 
• 27096-64-6 2-(allyloxy)aniline 
• 88-75-5 2-hydroxynitrobenzene 
• 65347-84-4 (2-Propoxy-phenyl)-carbamic acid 2-morpholin-4-yl-ethyl ester 
• 3079-53-6 1-nitro-2-propoxybenzene 
• 86255-27-8 silver(I) 2-nitrophenoxide 

Downstream Products

• 101602-54-4 N-[2-(6-methyl-[2]pyridyl)-ethyl]-2-propoxy-aniline 
• 32223-62-4 2-propoxyphenyl isocyanate 
• 98771-56-3 ethyl 1,6-dihydro-2-(2-propoxyanilino)-6-oxo-5-pyrimidinecarboxylate 
• 374909-84-9 (4,4,7,8-tetramethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene)(2-propoxyphenyl)amine 
• 114559-72-7 1-((1R,3R,5S)-8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(2-propoxy-phenyl)-urea 
• 98772-02-2 1,6-dihydro-2-(2-propoxyanilino)-6-oxo-5-pyrimidinecarboxylic acid 
• 553-79-7 2-amino-4-nitro-1-propoxybenzene 
• 106589-00-8 2-amino>isophthalic acid 
• 857825-61-7 1-iodo-2-propoxybenzene 
• 55792-51-3 acetic acid-(2-propoxy-anilide) 
• 109090-42-8 2-propoxy-N-(2-[4]pyridyl-ethyl)-aniline 

Relevant articles and documents

Investigation of hydro-lipophilic properties of n-alkoxyphenylhydroxynaphthalenecarboxamides ?

The evaluation of the lipophilic characteristics of biologically active agents is indispensable for the rational design of ADMET-tailored structure–activity models. N-Alkoxy-3-hydroxynaphthalene-2-carboxanilides, N-alkoxy-1-hydroxynaphthalene-2-carboxanilides, and N-alkoxy-2-hydroxynaphthalene-1-carboxanilides were recently reported as a series of compounds with antimycobacterial, antibacterial, and herbicidal activity. As it was found that the lipophilicity of these biologically active agents determines their activity, the hydro-lipophilic properties of all three series were investigated in this study. All 57 anilides were analyzed using the reversed-phase high-performance liquid chromatography method for the measurement of lipophilicity. The procedure was performed under isocratic conditions with methanol as an organic modifier in the mobile phase using an end-capped non-polar C18 stationary reversed-phase column. In the present study, a range of software lipophilicity predictors for the estimation of clogP values of a set of N-alkoxyphenylhydroxynaphthalenecarboxamides was employed and subsequently cross-compared with experimental parameters. Thus, the empirical values of lipophilicity (logk) and the distributive parameters (π) were compared with the corresponding in silico characteristics that were calculated using alternative methods for deducing the lipophilic features. To scrutinize (dis)similarities between the derivatives, a PCA procedure was applied to visualize the major differences in the performance of molecules with respect to their lipophilic profile, molecular weight, and violations of Lipinski’s Rule of Five.

Synthesis and Biological Evaluation of N-Alkoxyphenyl-3-hydroxynaphthalene-2-carboxanilides

A series of fifteen new N-alkoxyphenylanilides of 3-hydroxynaphthalene-2-carboxylic acid was prepared and characterized. Primary in vitro screening of the synthesized compounds was performed against Staphylococcus aureus, three methicillin-resistant S. aureus strains, Mycobacterium tuberculosis H37Ra and M. avium subsp. paratuberculosis. Some of the tested compounds showed antibacterial and antimycobacterial activity against the tested strains comparable with or higher than that of the standards ampicillin or rifampicin. 3-Hydroxy-N-(2-propoxyphenyl)naphthalene-2-carboxamide and N-[2-(but-2-yloxy)-phenyl]-3-hydroxynaphthalene-2-carboxamide had MIC = 12 μM against all methicillin-resistant S. aureus strains; thus their activity is 4-fold higher than that of ampicillin. The second mentioned compound as well as 3-hydroxy-N-[3-(prop-2-yloxy)phenyl]-naphthalene-2-carboxamide had MICs = 23 μM and 24 μM against M. tuberculosis respectively. N-[2-(But-2-yloxy)phenyl]-3-hydroxynaphthalene-2-carboxamide demonstrated higher activity against M. avium subsp. paratuberculosis than rifampicin. Screening of the cytotoxicity of the most effective antimycobacterial compounds was performed using THP-1 cells, and no significant lethal effect was observed for the most potent compounds. The compounds were additionally tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. N-(3-Ethoxyphenyl)-3-hydroxynaphthalene-2-carboxamide (IC50 = 4.5 μM) was the most active PET inhibitor. The structure-activity relationships are discussed.

COUMARIN DERIVATIVES AND METHODS OF USE IN TREATING HYPERPROLIFERATIVE DISEASES

Coumarin derivative compounds and methods for the treatment of hyperproliferative diseases, such as cancer, polycystic kidney disease, and fibrosis of different tissues (e.g., idiopathic pulmonary fibrosis), are provided. The methods include administering