447-27-8Relevant academic research and scientific papers
Creation of an α-mannosynthase from a broad glycosidase scaffold
Yamamoto, Keisuke,Davis, Benjamin G.
supporting information; experimental part, p. 7449 - 7453 (2012/09/21)
α-Mannosides made easy: Mutation of a family-GH31 α-glucosidase that displays plasticity to alterations at the 2-OH position of donor substrates created an efficient α-mannoside-synthesizing biocatalyst. A simple fluoride donor reagent was used for the synthesis of a range of mono-α-mannosylated conjugates using the α-mannosynthase displaying low (unwanted) oligomerization activity. Copyright
Synthesis of 1-[18F]fluorodeoxyglucose: An unexpected rearrangement in the reaction of 2-O-methanesulfonyl-β-D-mannopyranose with [18F]fluoride
De Groot, Tjibbe,Bormans, Guy,Busson, Roger,Mortelmans, Luc,Verbruggen, Alfons
, p. 147 - 157 (2007/10/03)
2-O-Methanesulfonyl-β-D-mannose was reacted with kryptofix/K2CO3/[18F]fluoride in CH3CN/THF (9:1) at 60°C. Unexpectedly, a mixture of 1α- and 1β-glucopyranosyl [18F]fluoride (4 and 5, respectively) was obtained in 50% radiochemical yield (EOB); 2-[18F]FDG was not detected. Modification of temperature, solvent or pH did not result in the formation of 2-[18F]FDG. Uptake of radioactivity in heart and brain of mice was significantly lower for 4 and 5 than for 2-[18F]FDG, although 5 seems to pass the blood-brain barrier. Uptake in bone was more pronounced for 4 than for 5 and negligible for 2-[18F]FDG.
