4474-18-4

Usage

InChI:InChI=1/C2HClN2O/c3-2(1-4)5-6/h6H

Upstream product

• 4732-58-5 (E,E)-monochloroglyoxime 
• 17019-15-7 (1Z,2E)-N-hydroxy-2-(hydroxyimino)-acetimidoyl chloride 
• 4732-58-5 chloroglyoxime 

Downstream Products

• 14442-24-1 5-phenylisoxazole-3-carbonitrile 
• 113682-17-0 exo-4-phenyl-8-cyano-3,5,10-trioxa-9-azabicyclo<5,3,0>-8-decene 
• 113682-17-0 endo-4-phenyl-8-cyano-3,5,10-trioxa-9-azabicyclo<5,3,0>-8-decene 
• 128889-62-3 4-(p-bromophenyl)-6-exo-3-(3-cyano-2-isoxazolin-5-yl)-6-endo-methyl-2-oxa-3-azabicyclo<3.1.0>hex-2-ene 
• 1201794-84-4 5-ethoxy-4,5-dihydroisoxazole-3-carbonitrile 
• 14442-22-9 5-phenyl-4,5-dihydro-isoxazole-3-carbonitrile 

Relevant academic research and scientific papers

SOLID FORMS OF (1R,2S,3R)-1-(2-(ISOXAZOL-3-YL)-1H-IMIDAZOL-4-YL)BUTANE-1,2,3,4-TETRAOL AND METHODS OF THEIR USE

Solid forms of (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol and hydrates thereof are disclosed, as well as compositions comprising them and methods of their use.

Methods for the Stereoselective Cis Cyanohydroxylation and Carboxyhydroxylation of Olefins

Two valuable reagents for the cis-specific vicinal cyanohydroxylation and carboxyhydroxylation of olefins are described.The cyanohydroxylation process is based on the decarboxylative ring opening of 3-carboxyisoxazolines prepared by the cycloaddition reaction of carbethoxyformonitrile oxide with various alkenes.Fragmentation of the isoxazolines prepared from cis- and trans-2-butene has been found to occur without any crossover in stereochemistry.The carboxyhydroxylation process begins with the dipolar cycloaddition reaction of the nitrile oxide derived from thetetrahydropyranyl ether derivative of 2-nitroethanol.Deprotection, hydrogenation, and oxitative cleavage of the derived dihydroxy ketone yield the stereochemcally pure β-hydroxy carboxylic acid.