447414-44-0Relevant academic research and scientific papers
Searching for cyclin-dependent kinase inhibitors using a new variant of the cope elimination
Griffin, Roger J.,Henderson, Andrew,Curtin, Nicola J.,Echalier, Aude,Endicott, Jane A.,Hardcastle, Ian R.,Newell, David R.,Noble, Martin E. M.,Wang, Lan-Zhen,Golding, Bernard T.
, p. 6012 - 6013 (2007/10/03)
β-Piperidinoethylsulfides are oxidized by m-chloroperbenzoic acid to intermediates containing both N-oxide and sulfone functions. These undergo a Cope-type elimination to a vinylsulfone that can be captured by amines to afford β-aminoethylsulfones. When a
An unusual behaviour of N-(tert-butoxycarbonyl)- and N-pivaloyl-(methylthio)anilines in metallation reactions
Cabiddu, Maria Grazia,Cabiddu, Salvatore,Cadoni, Enzo,De Montis, Stefania,Fattuoni, Claudia,Melis, Stefana
, p. 2893 - 2897 (2007/10/03)
The metallation reaction of N-Boc-and N-Piv-(methylthio)anilines are here described. The results show that N-Boc derivatives are metallated only by superbases to give products substituted at the thiomethylic group. N-Piv derivatives show a different behaviour: ortho-derivative is metallated by both butyllithium and superbase at the thiomethylic carbon atom, while para-derivative is metallated in ortho to the N-Piv group by butyllithium and at the thiomethylic carbon atom by superbase. The meta-derivative is metallated only by superbase at the thiomethylic carbon atom.
