447424-18-2

Upstream product

• 100-39-0 benzyl bromide 
• 5840-66-4 4-(benzyloxy)benzene-1,2-dicarboxylic acid 
• 610-35-5 4-hydroxyphthalic acid 
• 447424-14-8 6-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid 
• 1332697-25-2 ethyl 6-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-{[(trifluoromethyl)sulfonyl]oxy}-1,2-dihydroisoquinoline-3-carboxylate 
• 447424-27-3 ethyl 6-(benzyloxy)-4-hydroxy-2-(2-methylpropyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 447424-17-1 2-{[6-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}-1H-isoindole-1,3(2H)-dione 
• 447424-16-0 6-(benzyloxy)-3-(chloromethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one 
• 447424-15-9 6-(benzyloxy)-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one 
• 1332697-26-3 C₂₉H₂₉NO₄ 
• 5840-65-3 5-(benzyloxy)-2-benzofuran-1,3-dione 

Downstream Products

• 447424-19-3 tert-butyl {[6-hydroxy-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate 
• 447424-20-6 tert-butyl {[6-(2-amino-2-oxoethoxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate 
• 447416-94-6 2-{[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-6-yl]oxy}acetamide hydrochloride 
• 1332697-02-5 3-(aminomethyl)-6-hydroxy-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one hydrochloride 

Relevant academic research and scientific papers

Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: A new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554

The design, synthesis, and structure-activity relationships of a new class of potent and orally active non-peptide dipeptidyl peptidase IV (DPP-4) inhibitors, 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones, are described. We hypothesized that the 4-ph