5840-65-3

Upstream product

• 27550-59-0 4-hydroxyphthalic anhydride 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 610-35-5 4-hydroxyphthalic acid 

Downstream Products

• 203441-51-4 5-Benzyloxy-2-(3-cyclopentyloxy-4-methoxy-phenyl)-indan-1,3-dione 
• 94464-27-4 2-(2,6-dioxo-3-piperidinyl)-5-benzyloxy-1H-isoindole-1,3(2H)-dione 
• 928776-62-9 5-benzyloxy-2-(1-benzyloxy-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 
• 928776-72-1 5-benzyloxy-2-(5-tert-butyldimethylsilyloxy-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 
• 203440-63-5 2-(3-Cyclopentyloxy-4-methoxy-phenyl)-5-hydroxy-2-pyridin-4-ylmethyl-indan-1,3-dione 
• 203439-50-3 5-Benzyloxy-2-(3-cyclopentyloxy-4-methoxy-phenyl)-2-pyridin-4-ylmethyl-indan-1,3-dione 
• 1002761-48-9 N-4-benzyloxyphthaloyl-(S)-tert-leucine 
• 447424-27-3 ethyl 6-(benzyloxy)-4-hydroxy-2-(2-methylpropyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylate 
• 447424-26-2 ethyl 7-(benzyloxy)-4-hydroxy-2-(2-methylpropyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylate 

Relevant academic research and scientific papers

Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: A new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554

The design, synthesis, and structure-activity relationships of a new class of potent and orally active non-peptide dipeptidyl peptidase IV (DPP-4) inhibitors, 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones, are described. We hypothesized that the 4-ph

Syntheses of aromatic substituted 6′-thiothalidomides

A resurgence of interest in thalidomide has occurred as a consequence of its diverse immunomodulatory and anticancer actions, which has fuelled interest in synthetic analogues with higher potencies or less undesirable side effect profiles. Several novel aromatic substituted 6′-thiothalidomides were synthesized whose synthetic route and strategy were developed on the basis of an analysis of reaction mechanisms. The regioselectivity of mono-thionation of aromatic substituted thalidomides with Lawesson's reagent is described, and the chemoselectivity of hydrogenation between the nitro group and 6′-thiocarbonyl group is discussed. Full characterization of eight substituted 6′-thiothalidomides is reported. Georg Thieme Verlag Stuttgart.

Mono- and dihydroxylated metabolites of thalidomide: Synthesis and TNF-α production-inhibitory activity

Mono- and dihydroxylated metabolites of thalidomide were efficiently prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. 5,N-Dihydroxythalidomide was a much more potent TNF-α production inhibitor than thalidomide.