447460-49-3Relevant articles and documents
Triaryl bis-sulfones as cannabinoid-2 receptor ligands: SAR studies
Shankar, Bandarpalle B.,Lavey, Brian J.,Zhou, Guowei,Spitler, James A.,Tong, Ling,Rizvi, Razia,Yang, De-Yi,Wolin, Ronald,Kozlowski, Joseph A.,Shih, Neng-Yang,Wu, Jie,Hipkin, R. William,Gonsiorek, Waldemar,Lunn, Charles A.
, p. 4417 - 4420 (2007/10/03)
We recently reported that compound 1 is a potent inhibitor of the CB2 receptor with high selectivity over CB1. This paper describes the SAR development for this class of compounds. Variation of the substitution pattern on the aromatic rings, as well as th